Metabolic scaling in solid tumours

Milotti, Edoardo and Vyshemirsky, Vladislav and Sega, Michela and Stella, Sabrina and Chignola, Roberto (2013) Metabolic scaling in solid tumours. Scientific Reports, 3. 1938. ISSN 2045-2322

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    Abstract

    Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. Recently, by combining the diffusion of oxygen, nutrients, and metabolites in the extracellular environment, and the internal motions that mix live and dead cells, we derived a growth law of solid tumours which is linked to parameters at the cellular level1. Here we use this growth law to obtain a metabolic scaling law for solid tumours, which is obeyed by tumours of different histotypes both in vitro and in vivo, and we display its relation with the fractal dimension of the distribution of live cells in the tumour mass. The scaling behaviour is related to measurable parameters, with potential applications in the clinical practice.