Picture map of Europe with pins indicating European capital cities

Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

The vitreous humor as a barrier to nanoparticle distribution

Mains, Jenifer and Wilson, Clive (2012) The vitreous humor as a barrier to nanoparticle distribution. Journal of Ocular Pharmacology and Therapeutics. ISSN 1080-7683

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocular drug delivery systems. The gel structure and biochemical components of the vitreous will impact on the rate of nanoparticle movement through the tissue to reach the retinal tissue. As well as structure of the vitreous, flow systems operating within the vitreous, age-related structural changes, and the presence of inflammation will also have a potential effect on movement. To effectively target the posterior retina, the physical properties of the nanoparticle formulation are a key element in the design of a system that will penetrate through the vitreous barrier.