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Pharmacy-implemented guidelines on switching from intravenous to oral antibiotics: an intervention study

McLaughlin, C.M. and Bodasing, N. and Boyter, A.C. and Fenelon, C. and Fox, J.G. and Seaton, A.V. (2005) Pharmacy-implemented guidelines on switching from intravenous to oral antibiotics: an intervention study. Quarterly Journal of Medicine, 98 (10). pp. 745-752. ISSN 1460-2725

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A high proportion of medical in-patients in the UK receive intravenous (IV) antibiotic therapy. This may be inappropriate in non-severe infections, or unnecessarily prolonged. Data relating to infection and antibiotic therapy were collected for 4 weeks pre-intervention (group 1) and 4 weeks post intervention (group 2). Six months later, data were collected for a further 4 weeks following a second intervention (group 3). Interventions consisted of pharmacy-led implementation of guidelines incorporating criteria for IV therapy and switching to the oral route. The second intervention also included pharmacy-initiated feedback on prescribing. The main outcome measures were IV antibiotic duration, and appropriateness of the IV route and switching.