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Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

Liu, H. B. and Edrada-Ebel, R. and Ebel, R. and Wang, Y. and Schulz, B. and Draeger, S. and Muller, W. E. G. and Wray, V. and Lin, W. H. and Proksch, P. (2011) Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus. Helvetica Chimica Acta, 94 (4). pp. 623-631. ISSN 0018-019X

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Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.