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Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

Chalmers, Susan and Caldwell, S.T. and Quin, C and Prime, T.A. and James, A.M. and Cairns, Alan and Murphy, M.P. and McCarron, John and Hartley, R.C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134 (2). pp. 758-761.

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Abstract

Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.