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Detection of specific biomarkers within single cells using SERS and nanosensing

Graham, Duncan and Larmour, Iain and Argueta, Erick (2010) Detection of specific biomarkers within single cells using SERS and nanosensing. Abstracts of papers - American Chemical Society, 240. -. ISSN 0065-7727

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Abstract

Silver nanoparticle seeds will be prepared by a photochemical route followed by irradiation with LEDs of specific wavelengths which gives the ability to tune the absorbance profiles. Therefore, within a surface enhanced Raman spectroscopy (SERS) experiment there will be an additional resonance enhancement of the signal when the laser couples to the nanoparticle absorbance, something which usually requires aggregation of standard nanoparticle solutions when using longer wavelengths (e.g. 633/785 nm). One of the main aims of this project will be to compare a dimer enriched nanotag solution (which contains enhancing hot-spots) with nanotags formed by single nanoparticles with an absorbance tuned to the laser wavelength. Other areas of work will include the preparation of suitable nanoparticles for all laser lines within the laboratory providing group members nanoparticles which are free of surfactants and capping agents. These are normally used to direct and control their growth, allowing them to be readily functionalised for nanobiotechnology applications. Having these nanoparticles will also allow us to compare the SERS enhancements of the formed nanoparticles with aggregated colloids at various wavelengths.