Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment
Wheate, N.J. and Day, A.I. and Blanch, R.J. and Arnold, A.P. and Cullinane, C. and Collins, J.G. (2004) Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment. Chemical Communications (London), 12. pp. 1424-1425. ISSN 0009-241X (https://doi.org/10.1039/b404358h)
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The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.
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Item type: Article ID code: 39057 Dates: DateEvent2004PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 10 Apr 2012 14:52 Last modified: 08 Apr 2024 16:35 URI: https://strathprints.strath.ac.uk/id/eprint/39057
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