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Strathprints makes available Open Access scholarly outputs exploring both the technical aspects of computer security, but also the regulation of existing or emerging technologies. A research specialism of the Department of Computer & Information Sciences (CIS) is computer security. Researchers explore issues surrounding web intrusion detection techniques, malware characteristics, textual steganography and trusted systems. Digital forensics and cyber crime are also a focus.

Meanwhile, the School of Law and its Centre for Internet Law & Policy undertake studies on Internet governance. An important component of this work is consideration of privacy and data protection questions and the increasing focus on cybercrime and 'cyberterrorism'.

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Natural products isolation in modern drug discovery programs

Gray, Alexander I and Igoli, John O and Edrada-Ebel, Ruangelie (2012) Natural products isolation in modern drug discovery programs. Methods in Molecular Biology, 864. pp. 515-34.

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Abstract

Natural products play a vital role in drug discovery. They have served as the basic reference and initiators in drug discovery programs. Natural products as pure compounds have been involved in western medicine as drugs or lead compounds for drug discovery and development. In traditional medicine, they have been involved for a very long time as medicinal extracts, infusions, decoctions, or other therapeutic preparations. Modern drug discovery programs require an arsenal of drug candidate molecules in pure form whose activities (usually against cells or enzymes) are rapidly determined using high-throughput screening (HTS) and activities are expected in micro- (μM) to nanomolar (nM) levels. The difficulty in meeting today's standards for drug candidate molecules poses the question: are natural products still relevant in modern drug discovery programs? This and other issues, including the spectroscopic investigation of crude extracts, are discussed.