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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Natural products isolation in modern drug discovery programs

Gray, Alexander I and Igoli, John O and Edrada-Ebel, Ruangelie (2012) Natural products isolation in modern drug discovery programs. Methods in Molecular Biology, 864. pp. 515-34.

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Abstract

Natural products play a vital role in drug discovery. They have served as the basic reference and initiators in drug discovery programs. Natural products as pure compounds have been involved in western medicine as drugs or lead compounds for drug discovery and development. In traditional medicine, they have been involved for a very long time as medicinal extracts, infusions, decoctions, or other therapeutic preparations. Modern drug discovery programs require an arsenal of drug candidate molecules in pure form whose activities (usually against cells or enzymes) are rapidly determined using high-throughput screening (HTS) and activities are expected in micro- (μM) to nanomolar (nM) levels. The difficulty in meeting today's standards for drug candidate molecules poses the question: are natural products still relevant in modern drug discovery programs? This and other issues, including the spectroscopic investigation of crude extracts, are discussed.