Diethylphosphine oxide (DEPO): high-yielding and facile preparation of indolones in water
Murphy, J.A. and Khan, T.A. and Tripoli, R. and Crawford, J.J. and Martin, C.G. (2003) Diethylphosphine oxide (DEPO): high-yielding and facile preparation of indolones in water. Organic Letters, 5 (16). pp. 2971-2974. ISSN 1523-7060 (https://doi.org/10.1021/ol035173i)
Full text not available in this repository.Request a copyAbstract
Indolones are prepared in excellent yield at 80 °C in water by radical reaction (aryl radical formation, hydrogen atom abstraction, cyclization, and rearomatization) mediated by the reagent diethylphosphine oxide (DEPO). The reaction features V-501 as a water-soluble initiator; no other additives are needed. The process proceeds at a much lower temperature than is required for efficient reaction with toxic tributyltin hydride in benzene and permits significantly higher isolated yields than the corresponding reaction mediated by ethylpiperidine hypophosphite (EPHP).
-
-
Item type: Article ID code: 38514 Dates: DateEvent2003PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 14 Mar 2012 16:04 Last modified: 04 Sep 2024 18:39 URI: https://strathprints.strath.ac.uk/id/eprint/38514