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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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The relationships between muscle strength, biomechanical functional moments and health-related quality of life in non-elite older adults

Samuel, Dinesh and Rowe, Philip and Hood, Victoria and Nicol, Alexander (2012) The relationships between muscle strength, biomechanical functional moments and health-related quality of life in non-elite older adults. Age and ageing, 41 (2). pp. 224-230.

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Aims to investigate the association between muscle strength, biomechanical functional moments during everyday tasks and health-related quality of life (HRQoL) in older adults. Eighty-four healthy adults aged 60-88 years were tested. A torque dynamometer was utilised to measure muscle moments at the knee and hip joints. Functional assessment involved three-dimensional biomechanical analysis of gait, chair rise and sit-down, stair ascent and descent using an 8-camera VICON® system with Kistler force plates. HRQoL was assessed using the Short Form-36 (SF-36) questionnaire.Spearman's correlation coefficient showed significant correlation (P < 0.001) between isometric strength and functional moments (r = 0.24–0.67). Muscle strength was significantly correlated with SF-36 scores, including physical functioning, bodily pain, vitality, social functioning and role emotional scores. Knee flexion moment was correlated with role physical, vitality, social functioning, role emotional, mental health and mental component scores (r = 0.24–0.40). Loss of muscle strength is associated with poorer functional ability and both are associated with reduced HRQoL. The reduction in HRQoL is considerable in the physical functioning domain. Cause and effect was not established but studies need to be undertaken to evaluate the benefits of strength training, functional activity training or increased participation in life.