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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Parameter estimation of signal transduction pathways using probability density function of measurement

Liu, T.Y. and Jia, J.F. and Wang, H. and Yue, H. (2007) Parameter estimation of signal transduction pathways using probability density function of measurement. In: The 1st International Conference on Biomedical Engineering, 2007. ICBBE 2007, 2007-07-06.

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Abstract

Parameter estimation of signal transduction pathway models is a challenging task as such models are normally nonlinear, high dimensional, and the measurement data is limited and corrupted by noise. In this paper, a novel method for parameter estimation is proposed, in which the distance between the probability density function (PDF) of the model output and the PDF of the measurement data is minimized. This method has been applied to estimate unknown parameters of a TNFalpha- mediated NF-kappaB signal transduction pathway model. The simulation results show the effectiveness of this new algorithm.