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One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Stonehouse, Jeffrey and Chekmarev, Dmitriy and Ivanova, Natalya and Lang, Stuart and Pairaudeau, Garry and Smith, Neal and Stocks, Michael and Sviridov, Sergey and Utkina, Lyubov (2008) One-pot four-component reaction for the generation of pyrazoles and pyrimidines. Synlett (1). pp. 100-104. ISSN 0936-5214

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Abstract

The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process