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Chromatographic performance of molecularly imprinted polymers: Core-shell microspheres by precipitation polymerization and grafted MIP films via iniferter-modified silica beads

Barahona, Francisco and Turiel, Esther and Cormack, Peter A. G. and Martin-Esteban, Antonio. (2010) Chromatographic performance of molecularly imprinted polymers: Core-shell microspheres by precipitation polymerization and grafted MIP films via iniferter-modified silica beads. Journal of Polymer Science Part A: Polymer Chemistry, 48 (5). pp. 1058-1066. ISSN 0887-624X

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Abstract

In this work, two different surface imprinting formats have been evaluated using thiabendazole (TBZ) as model template. The first format is a thin film of molecularly imprinted polymer (MIP) grafted from preformed silica particles using an immobilized iniferter-type initiator (inif-MIP). The second format is molecularly imprinted polymer microspheres with narrow particle size distribution and core-shell morphol. prepd. by pptn. polymn. in a two-step procedure. For the latter format, polymer microspheres (the core particles) were obtained by pptn. polymn. of divinylbenzene-80 (DVB-80) in acetonitrile. Thereafter, the core particles were used as seed particles in the synthesis of MIP shells by copolymn. of DVB-80 and methacrylic acid in the presence of TBZ in a mixed solvent porogen (acetonitrile/toluene). The materials were characterized by elemental microanal., nitrogen sorption porosimetry and scanning (and transmission) electron microscopy. Thereafter, the imprinted materials were assessed as stationary phases in liq. chromatog. From this study it can be concluded that grafted MIP beads can be obtained in a simple and direct manner, consuming only a fraction of the reagents used typically to prep. imprinted particles from a monolithic imprinted polymer. Such materials can be used in the development of in-line molecularly imprinted solid-phase extn. methods. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1058-1066, 2010.