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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Squamo-columnar junction locator probe : an in vivo validation study

Lee, Y. Y. and Whiting, J. G. H. and Robertson, E. V. and Seenan, J. P. and Derakhshan, M. H. and Wirz, A. and Connolly, P. and McColl, K. E. L. (2011) Squamo-columnar junction locator probe : an in vivo validation study. Gut, 60 (Supple). A181-A182. ISSN 0017-5749

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Abstract

Introduction The gastro-oesophageal junction is very mobile and constantly changing position with breathing, swallowing and transient lower oesophageal sphincter relaxation (TLESR). The only method currently available for studying its location is fluoroscopic screening and this is limited by radiation exposure. We have developed a method allowing continuous real-time monitoring of the squamo-columnar (SC) junction without radiation exposure. It involves clipping a small magnet endoscopically to the SC junction and monitoring its location by a series of 26 Hall Effect sensors placed at 5 mm interval within a probe placed in oesophageal lumen. The aim of the study was to validate the new technique against fluoroscopy. Methods In eight subjects, the magnet was attached and locator probe inserted. During simultaneous fluoroscopy, subjects were asked to perform normal breathing, deep breathing, water swallows and finally advancement and retraction of locator probe over 12 cm segment. The fluoroscopy recorded images at a rate of 5 frames per seconds and the locator at 8 Hz. The position recorded by fluoroscopy and locator at each second interval were compared as well as amplitude of each complete manoeuvre. Results The correlation co-efficient for all 224 position readings was 0.96 (95% CI 0.89 to 0.96) and adjusted residual squared (R2) of 0.91. The amplitude for the different manoeuvres was similar by the two techniques. Conclusion The locator allows continuous monitoring of the location of the SC junction with an accuracy equivalent to fluoroscopic screening and without any radiation exposure