High throughput screening approach to lead discovery

Rankovic, Zoran and Jamieson, Craig and Morphy, Richard.; (2010) High throughput screening approach to lead discovery. In: Lead Generation Approaches in Drug Discovery. Wiley-VCH, Hoboken, NJ, pp. 21-71. ISBN 978-0-470-25761-6

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Abstract

A review. A review on high throughput screening (HTS) strategies for lead discovery. Topics covered include: historical background; screening collection enhancement strategies; HTS assays and equipment; hit confirmation and assessment; and successes, failures, and examples of HTS.