Strategy and tactics for hERG optimizations

Jamieson, Craig and Moir, Elizabeth M. and Rankovic, Zoran and Wishart, Grant. (2008) Strategy and tactics for hERG optimizations. In: Antitargets. Methods and Principles in Medicinal Chemistry, 38 . Wiley-VCH, Weinheim, Germany, pp. 423-455. ISBN 978-3-527-31821-6

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Abstract

A review on the approaches used to circumvent activity at human ether-a-go-go related gene (hERG), identified through an extensive survey of the medicinal chem. literature until the end of 2006. [on SciFinder(R)]