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Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

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Micro-/nano-patterning of DNA and rapid readout with SERS tags

Sun, Shuqing and Thompson, David and Schmidt, Ute and Graham, Duncan and Leggett, Graham J. (2010) Micro-/nano-patterning of DNA and rapid readout with SERS tags. Chemical Communications (London), 46 (29). pp. 5292-5294. ISSN 0009-241X

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Abstract

Hybridisation of oligonucleotide micro-and nano-structures, formed using far-and near-field optical lithography, with Raman dye-labelled silver nanoparticles functionalised with complementary oligonucleotides yields striking contrast, attributed to Raman "hot-spot'' formation, and enables rapid, convenient read-out by Raman microscopy.