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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Brain delivery of peptides and proteins

Dufès, Christine (2011) Brain delivery of peptides and proteins. In: Peptide and protein delivery. Elsevier, pp. 105-122. ISBN 978-0-12-384935-9

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Abstract

Therapeutic proteins and peptides have been identified as showing great promise for the treatment of brain cancers and neurodegenerative diseases. However, their delivery to their intended site of action from the blood is hampered by the presence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. Peptides generally do not cross the BBB because these highly polar compounds are not lipid-soluble, and because most circulating peptides do not have access to specialized, BBB receptor-mediated transport systems. Over the past three decades, research has led to a better understanding of the transport mechanisms at the BBB, and to the development of several strategies for improving the delivery of peptides/proteins to the central nervous system (CNS).