Structure based evolution of a novel series of positive modulators of the AMPA receptor

Jamieson, Craig and Maclean, John K.F. and Brown, Christopher I and Campbell, Robert A and Gillen, Kevin J. and Gillespie, Jonathan and Kazemier, Bert and Kiczun, Michael and LAMONT, YVONNE and Lyons, Amanda J. and Moir, Elizabeth M. and Morrow, John A. and Pantling, John and Rankovic, Zoran and Smith, Lynn (2011) Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21 (2). pp. 805-811. ISSN 0960-894X

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    Abstract

    Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X

    Creators(s): Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272, Maclean, John K.F., Brown, Christopher I, Campbell, Robert A, Gillen, Kevin J., Gillespie, Jonathan, Kazemier, Bert, Kiczun, Michael, LAMONT, YVONNE, Lyons, Amanda J., Moir, Elizabeth M., Morrow, John A., Pantling, John, Rankovic, Zoran and Smith, Lynn;
    Item type:Article
    ID code:31485
    Keywords:AMPA receptor , allosteric modulator, SBDD, indane, scaffold hopping, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:14 Jun 2011 13:11
    Last modified:20 Jan 2021 19:23
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/31485
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