Structure based evolution of a novel series of positive modulators of the AMPA receptor

Jamieson, Craig and Maclean, John K.F. and Brown, Christopher I and Campbell, Robert A and Gillen, Kevin J. and Gillespie, Jonathan and Kazemier, Bert and Kiczun, Michael and LAMONT, YVONNE and Lyons, Amanda J. and Moir, Elizabeth M. and Morrow, John A. and Pantling, John and Rankovic, Zoran and Smith, Lynn (2011) Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21 (2). pp. 805-811. ISSN 0960-894X

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    Abstract

    Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X