Structure based evolution of a novel series of positive modulators of the AMPA receptor

Jamieson, Craig and Maclean, John K.F. and Brown, Christopher I and Campbell, Robert A and Gillen, Kevin J. and Gillespie, Jonathan and Kazemier, Bert and Kiczun, Michael and LAMONT, YVONNE and Lyons, Amanda J. and Moir, Elizabeth M. and Morrow, John A. and Pantling, John and Rankovic, Zoran and Smith, Lynn (2011) Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21 (2). pp. 805-811. ISSN 0960-894X

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    Abstract

    Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X

    ORCID iDs

    Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272, Maclean, John K.F., Brown, Christopher I, Campbell, Robert A, Gillen, Kevin J., Gillespie, Jonathan, Kazemier, Bert, Kiczun, Michael, LAMONT, YVONNE, Lyons, Amanda J., Moir, Elizabeth M., Morrow, John A., Pantling, John, Rankovic, Zoran and Smith, Lynn;
    • Item type:Article
      ID code:31485
      Dates:
      Date
      Event
      15 January 2011
      Published
      Keywords:AMPA receptor , allosteric modulator, SBDD, indane, scaffold hopping, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:14 Jun 2011 13:11
      Last modified:23 Sep 2021 04:01
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/31485
    CORE (COnnecting REpositories)