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Evaluation of transobturator tension-free vaginal tapes in management of women with recurrent stress urinary incontinence

Abdel-Fattah, Mohamed and Ramsay, Ian and Pringle, Stewart and Hardwick, Chris and Ali, Hassan and Young, David and Mostafa, Alyaa (2011) Evaluation of transobturator tension-free vaginal tapes in management of women with recurrent stress urinary incontinence. Urology, 77 (5). pp. 1070-1075. ISSN 0090-4295

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OBJECTIVES To assess the efficacy of transobturator tapes in the treatment of women with recurrent urodynamic stress incontinence. METHODS We performed a secondary analysis of a prospective, randomized, single-blinded study. A total of 341 women were recruited (April 2005 and April 2007) and randomly assigned to undergo "inside-out" TVT-O or "outside-in" TOT-ARIS. Of these women, 46 had undergone >= 1 previous continence procedures and were included in the present study. The preoperative assessment included a urodynamic assessment and completion of validated symptom severity and quality-of-life questionnaires. The primary outcome was the patient-reported success rate at 1 year as assessed using the Patient Global Impression of Improvement (very much/much improved). The secondary outcomes included changes in quality of life, sexual function, the objective success rates defined as negative findings on the standard 1-hour pad test, and a comparison between both routes of transobturator tapes. Multivariate analysis was performed to identify the risk factors for failure. RESULTS All 46 women completed the 1-year follow-up period. The patient-reported success rate and objective cure rate was 69.6% and 76.5%, respectively, with no significant differences between the 2 transobturator routes (P = .104, odds ratio [OR] 2.933, 95% confidence interval [CI] 0.803-10.719; and P = .077, OR 4.524, 95% CI 0.849-24.109, respectively). Of the 46 women, 35 (76.1%) reported >10-point improvement on the total King's Health Questionnaire scores and 71% of sexually active women (n = 22) showed an improvement in the total 12-item Pelvic Organ Prolapse/Incontinence Sexual Function Questionnaire scores. On multivariate analysis, a maximal urethral closure pressure of <30 cm H2O was the only independent risk factor for failure (P = .016, OR 9.206, 95% CI 1.511-56.104). CONCLUSIONS Transobturator tapes have good patient-reported and objective success rates at 1 year of follow-up in women with previous failed incontinence surgery. A low maximal urethral closure pressure was the only independent predictor of failure. UROLOGY 77: 1070-1075, 2011. (C) 2011 Elsevier Inc.