Picture water droplets

Developing mathematical theories of the physical world: Open Access research on fluid dynamics from Strathclyde

Strathprints makes available Open Access scholarly outputs by Strathclyde's Department of Mathematics & Statistics, where continuum mechanics and industrial mathematics is a specialism. Such research seeks to understand fluid dynamics, among many other related areas such as liquid crystals and droplet evaporation.

The Department of Mathematics & Statistics also demonstrates expertise in population modelling & epidemiology, stochastic analysis, applied analysis and scientific computing. Access world leading mathematical and statistical Open Access research!

Explore all Strathclyde Open Access research...

Bicyclic cyclopentenones via the combination of an iridium- catalyzed allylic substitution with a diastereoselective intramolecular Pauson–Khand reaction

Farwick, Andreas and Engelhart, Jens and Tverskoy, Olena and Welter, Carolin and Umlauf, Quendolin and Rominger, Frank and Kerr, William and Helmchen, Gunter (2011) Bicyclic cyclopentenones via the combination of an iridium- catalyzed allylic substitution with a diastereoselective intramolecular Pauson–Khand reaction. Advanced Synthesis and Catalysis, 353 (2-3). pp. 349-370. ISSN 1615-4150

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Enantioselective syntheses of bicyclic cyclopentenones are described. Key steps are an Ir-catalyzed allylic substitution and an intramolecular diastereoselective Pauson-Khand reaction. The diastereoselectivity of the Pauson-Khand reaction was found to be crucially dependent on the unit connecting the propargylic and the olefinic units of the precursor. Very high degrees of diastereoselection were obtained with an NBoc unit as connector. This methodology has been illustrated by application within an enantioselective formal total synthesis of (-)-α-kainic acid.