Thioctic acid modification of oligonucleotides using an H-phosphonate
Dougan, Jennifer A. and Reid, Andrew K. and Graham, Duncan (2010) Thioctic acid modification of oligonucleotides using an H-phosphonate. Tetrahedron Letters, 51 (44). pp. 5787-5790. ISSN 0040-4039 (https://doi.org/10.1016/j.tetlet.2010.08.107)
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The H-phosphonate of a derivative of thioctic acid (TA) was synthesized and used to introduce a disulfide moiety at the 5'-end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a cyclic disulfide in the starting alcohol. The disulfide-modified oligonucleotides are subsequently used in metallic nanoparticle (Au and Ag) and surface functionalisation for sensitive, sequence specific analytical detection strategies.
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Item type: Article ID code: 28671 Dates: DateEvent3 November 2010PublishedSubjects: Science > Science (General)
Science > ChemistryDepartment: Faculty of Science > Pure and Applied Chemistry Depositing user: Mrs Gillian Neeson Date deposited: 15 Nov 2010 10:08 Last modified: 08 Apr 2024 18:44 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/28671