High-pressure structural studies of the pharmaceutical, chlorothiazide

Oswald, I.D.H. and Lennie, Alistair R. and Pulham, C.R. and Shankland, K. (2010) High-pressure structural studies of the pharmaceutical, chlorothiazide. CrystEngComm, 12 (9). pp. 2533-2540. ISSN 1466-8033

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Abstract

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.