A two-layer diffusive model for describing the variability of transdermal drug permeation
Meidan, V.M. and Pritchard, D. (2010) A two-layer diffusive model for describing the variability of transdermal drug permeation. European Journal of Pharmaceutics and Biopharmaceutics, 74 (3). pp. 513-517. ISSN 0939-6411
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There is mounting evidence that the permeability coefficients (kp) that describe any given transdermal drug permeation process generally follow some form of positively skewed, non-symmetrical distribution rather than a simple normal distribution. Yet a suitable theoretical treatment of this area has not been undertaken to date. In this paper, we describe a two-layer model that can explain five drugs' kp variabilities as measured in two previously published papers. The model shows why rapidly permeating drugs would tend to exhibit more symmetrical kp distributions while progressively more slowly permeating drugs would tend to exhibit progressively more positively skewed kp distributions. Future research should take this effect into account when comparing the flux variabilities of hydrophilic and lipophilic drugs.
Creators(s): |
Meidan, V.M. and Pritchard, D. ![]() | Item type: | Article |
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ID code: | 26160 |
Keywords: | transdermal , flux, permeation, variability, skewness, two-layer model, Therapeutics. Pharmacology, Pharmaceutical Science, Biotechnology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Mathematics and Statistics |
Depositing user: | Strathprints Administrator |
Date deposited: | 18 Apr 2011 10:12 |
Last modified: | 20 Jan 2021 19:01 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/26160 |
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