Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals
Oswald, I.D.H. and Pulham, C.R. (2008) Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals. CrystEngComm, 10 (9). pp. 1114-1116. ISSN 1466-8033
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Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2:1 co-crystal of paracetamol:piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2:1 co-crystal of paracetamol:piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.
| Creators(s): |
Oswald, I.D.H.  ORCID: https://orcid.org/0000-0003-4339-9392 and Pulham, C.R.;
| Item type: | Article |
|---|---|
| ID code: | 26041 |
| Keywords: | x-ray, polymorphs, paracetamol, diffraction, exploration, piracetam, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 20 Aug 2010 12:38 |
| Last modified: | 01 Jan 2021 04:42 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/26041 |
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