Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals

Oswald, I.D.H. and Pulham, C.R. (2008) Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals. CrystEngComm, 10 (9). pp. 1114-1116. ISSN 1466-8033

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Abstract

Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2:1 co-crystal of paracetamol:piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2:1 co-crystal of paracetamol:piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.