Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction
Milliken, P.H. and Wadsworth, R.M. (2002) Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction. Thorax, 57 (Supp.3). p. 75. ISSN 0040-6376 (https://doi.org/10.1136/thorax.57.suppl_3.iii48)
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Abstract
Superoxide is known to cause vascular damage and can consume protective NO that maintains a low pulmonary pressure. There is evidence suggesting that hypoxia upregulates NADH/NADPH oxidase and xanthine oxidase in the smooth muscle and endothelial cells of the pulmonary artery, increasing superoxide production. Superoxide dismutase (SOD) is widely distributed in the cells of the vasculature, destroying superoxide, however, the role of SOD in hypoxic vasoconstriction is unknown.1 Therefore, the effect of endogenous SOD inhibition and superoxide generation on hypoxic pulmonary vasoconstriction was investigated.
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Item type: Article ID code: 22843 Dates: DateEventDecember 2002PublishedNotes: Non-variant with 22982 (text different). Subjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Strathprints Administrator Date deposited: 12 Jul 2010 10:16 Last modified: 06 Sep 2024 16:05 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/22843