Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade

Marshall, G. and Rankin, A.C. and Kane, K.A. and Workman, A.J. (2006) Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade. European Heart Journal, 27 (Supple). p. 30. 389.

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Abstract

The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.