In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers
Kerr, William J. and Watson, Allan J. B. and Hayes, Douglas. (2008) In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers. Organic and Biomolecular Chemistry, 6 (7). pp. 1238-1243. ISSN 1477-0520 (https://doi.org/10.1039/b802082e)
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Abstract
Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes2Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high yielding one-pot process.
ORCID iDs
Kerr, William J. ORCID: https://orcid.org/0000-0002-1332-785X, Watson, Allan J. B. and Hayes, Douglas.;-
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Item type: Article ID code: 19739 Dates: DateEvent2008Published25 February 2008Published OnlineSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Strathprints Administrator Date deposited: 26 May 2010 19:22 Last modified: 20 Oct 2024 00:25 URI: https://strathprints.strath.ac.uk/id/eprint/19739
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