Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones

Kerr, William J. and Watson, Allan J. B. and Hayes, Douglas. (2008) Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones. Synlett, 2008 (9). pp. 1386-1390. ISSN 0936-5214 (https://doi.org/10.1055/s-2008-1072739)

Abstract

Di-tert-butylmagnesium has been found to be a reactive, yet non-nucleophilic and non-reductive, carbon-centred base for the deprotonation of a series of ketones. This reagent demonstrates equally high reactivity when used as either the pre-formed reagent, or in a more accessible one-pot protocol from the parent Grignard reagent, and offers improved atom-efficiency over more traditionally employed bases.

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• Item metadata

  Item type:	Article
  ID code:	19625
  Dates:	Date Event 23 May 2008 Published
  Notes:	M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2008:781418(Journal)
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Strathprints Administrator
  Date deposited:	27 May 2010 09:13
  Last modified:	08 Apr 2024 17:38
  URI:	https://strathprints.strath.ac.uk/id/eprint/19625