Major constituents of the predominant endophytic fungi from the nigerian plants bryophyllum pinnatum, morinda lucida and jathropha gossypiifolia

Sowemimo, A.A. and Edrada-Ebel, R. and Ebel, R. and Proksch, P. and Omobuwajo, O.R. and Adesanya, S.A. (2008) Major constituents of the predominant endophytic fungi from the nigerian plants bryophyllum pinnatum, morinda lucida and jathropha gossypiifolia. Natural Product Communications, 3 (8). pp. 1217-1222. ISSN 1934-578X

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Abstract

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.