Selective solid-phase extraction of amoxicillin and cephalexin from urine samples using a molecularly imprinted polymer
Beltran, Antoni and Marce, Rosa M. and Cormack, Peter A. G. and Sherrington, David C. and Borrull, Francesc (2008) Selective solid-phase extraction of amoxicillin and cephalexin from urine samples using a molecularly imprinted polymer. Journal of Separation Science, 31 (15). pp. 2868-2874. ISSN 1615-9306 (https://doi.org/10.1002/jssc.200800085)
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In this paper we describe, for the first time, a molecularly imprinted polymer (MIP) for the antibiotic amoxicillin (AMX), synthesised by a noncovalent molecular imprinting approach and used to extract AMX selectively from urine samples. The MIP was applied as a molecularly selective sorbent in molecularly imprinted SPE (MISPE) in an off-line mode, where it showed useful cross-selectivity for a structurally related antibiotic, cephalexin (M). By using a MISPE protocol, the MIP was able to selectively extract both AMX and CFX from 5 mL of water spiked with 10 mg/L with recoveries of 75 and 78% for AMX and CFX, respectively. When applied to real samples (urine) at clinically relevant concentrations, recoveries from 2 mL of human urine spiked with 20 mg/L decreased slightly to 65 and 63% for AMX and CFX, respectively. To demonstrate further the selectivity of the MIP obtained, a comparison with commercially available SPE cartridges was performed. Improvements in the retention of both AMX and CFX on the MIP were obtained relative to the commercially available cartridges, and the MISPE extracts were considerably cleaner, due to molecularly selective analyte binding by the MIP. Copyright © 2010 Thomson Reuters
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Item type: Article ID code: 19523 Dates: DateEvent19 August 2008Published12 May 2008AcceptedSubjects: Science > Chemistry
Science > Chemistry > Physical and theoretical chemistryDepartment: Faculty of Science > Pure and Applied Chemistry Depositing user: Strathprints Administrator Date deposited: 25 May 2010 09:03 Last modified: 08 Apr 2024 17:40 URI: https://strathprints.strath.ac.uk/id/eprint/19523