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Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor

Cutulic, S.P.Y. and Murphy, J.A. and Farwaha, H. and Zhou, S.Z. and Chrystal, E. (2008) Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor. Synlett (14). pp. 2132-2136. ISSN 0936-5214

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Abstract

The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.