Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor

Cutulic, S.P.Y. and Murphy, J.A. and Farwaha, H. and Zhou, S.Z. and Chrystal, E. (2008) Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor. Synlett (14). pp. 2132-2136. ISSN 0936-5214

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Abstract

The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.

ORCID iDs

Cutulic, S.P.Y., Murphy, J.A., Farwaha, H. ORCID logoORCID: https://orcid.org/0000-0003-0570-005X, Zhou, S.Z. and Chrystal, E.;