Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa

Ibrahim, S.R.M. and Edrada-Ebel, R.A. and Mohamed, G.A. and Youssef, D.T.A. and Wray, V. and Proksch, P. (2008) Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa. ARKIVOC - Online Journal of Organic Chemistry. pp. 164-171. ISSN 1551-7004

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Abstract

From the ethyl acetate fraction of the Indonesian sponge Callyspongia aerizusa extract, a new cyclic peptide named callyaerin G was isolated. Its structure was elucidated by extensive 1D and 2D NMR (1H NMR, TOCSY and ROESY) studies and mass spectrometric data (ESI- and FAB-MS). The stereochemistry was determined by Marfey's analysis. Callyaerin G was found to exhibit cytotoxic activity when tested against different cancer cell lines.

Creators(s): Ibrahim, S.R.M., Edrada-Ebel, R.A., Mohamed, G.A., Youssef, D.T.A., Wray, V. and Proksch, P.;
Item type:Article
ID code:19450
Keywords:callyspongia aerizusa, callyaerin G, marfey's analysis, cytotoxicity, Pharmacy and materia medica, Organic Chemistry
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date deposited:26 May 2010 10:17
Last modified:01 Jan 2021 09:16
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URI:https://strathprints.strath.ac.uk/id/eprint/19450
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