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Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa

Ibrahim, S.R.M. and Edrada-Ebel, R.A. and Mohamed, G.A. and Youssef, D.T.A. and Wray, V. and Proksch, P. (2008) Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa. ARKIVOC - Online Journal of Organic Chemistry. pp. 164-171. ISSN 1551-7004

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From the ethyl acetate fraction of the Indonesian sponge Callyspongia aerizusa extract, a new cyclic peptide named callyaerin G was isolated. Its structure was elucidated by extensive 1D and 2D NMR (1H NMR, TOCSY and ROESY) studies and mass spectrometric data (ESI- and FAB-MS). The stereochemistry was determined by Marfey's analysis. Callyaerin G was found to exhibit cytotoxic activity when tested against different cancer cell lines.