Characterization of wax granules containing paracetamol produced by a hot-melt spray system

Coombs, G.H. and Stevens, H.N.E. and Thorne, B. and Mullen, A. (2008) Characterization of wax granules containing paracetamol produced by a hot-melt spray system. Journal of Pharmacy and Pharmacology, 60 (S1). A61-A61. ISSN 0022-3573

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Abstract

Paracetamol of different particle-size ranges was incorporated into glyceryl monostearate (GMS) granules with the anticipation of producing a sustained-release oral delivery system from a hot-melt solid dispersion (Habib 2001). Subsequent characterization of these formulations indicated that drug release was dependent on particle size but not as anticipated by Noyes-Whitney (Martin et al 1983).