Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R.J. and Gracie, J.A. and McInnes, I.B. and Boyd, G.W. (2009) Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. Rheumatology, 48 (Supple). i38-i38. ISSN 1462-0324

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Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.

ORCID iDs

Dunning, L., Lockhart, J.C., Ferrell, W.R., Plevin, R.J. ORCID logoORCID: https://orcid.org/0000-0002-7849-1220, Gracie, J.A., McInnes, I.B. and Boyd, G.W.;