Vaccines against toxoplasma gondii : challenges and opportunities
Jongert, Erik and Roberts, Craig W and Gargano, Nicola and Förster-Wald, Elisabeth and Petersen, Eskild (2009) Vaccines against toxoplasma gondii : challenges and opportunities. Memorias do Instituto Oswaldo Cruz, 104 (2). pp. 252-266. ISSN 1678-8060 (https://doi.org/10.1590/S0074-02762009000200019)
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Abstract
Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects. Rodent models have been used in research on vaccines against T. gondii over the past decades. However, regardless of the vaccine construct, the vaccines have not been able to induce protective immunity when the organism is challenged with T. gondii, either directly or via a vector. Only a few live, attenuated T. gondii strains used for immunization have been able to confer protective immunity, which is measured by a lack of tissue cysts after challenge. Furthermore, challenge with low virulence strains, especially strains with genotype II, will probably be insufficient to provide protection against the more virulent T. gondii strains, such as those with genotypes I or II, or those genotypes from South America not belonging to genotype I, II or III. Future studies should use animal models besides rodents, and challenges should be performed with at least one genotype II T. gondii and one of the more virulent genotypes. Endpoints like maternal-foetal transmission and prevention of eye disease are important in addition to the traditional endpoint of survival or reduction in numbers of brain cysts after challenge.
ORCID iDs
Jongert, Erik, Roberts, Craig W ORCID: https://orcid.org/0000-0002-0653-835X, Gargano, Nicola, Förster-Wald, Elisabeth and Petersen, Eskild;-
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Item type: Article ID code: 19097 Dates: DateEvent31 March 2009Published4 December 2008AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Strathprints Administrator Date deposited: 15 Jun 2010 10:20 Last modified: 31 Oct 2024 01:34 URI: https://strathprints.strath.ac.uk/id/eprint/19097