A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus

Aly, A.H. and Debbab, A. and Edrada-Ebel, R.A. and Wray, V. and Muller, W.E.G. and Lin, W.H. and Ebel, R. and Proksch, P., BMBF (Funder), MOST (Funder) (2009) A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus. Zeitschrift fur Naturforschung C, 64 (5-6). pp. 350-354. ISSN 0939-5075

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Abstract

A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.

Creators(s): Aly, A.H., Debbab, A., Edrada-Ebel, R.A., Wray, V., Muller, W.E.G., Lin, W.H., Ebel, R. and Proksch, P.; BMBF (Funder), MOST (Funder);
Item type:Article
ID code:19014
Keywords:endophytes, chaetomium, natural products, structure elucidation, Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all)
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date deposited:24 May 2010 08:52
Last modified:02 Sep 2020 02:31
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URI:https://strathprints.strath.ac.uk/id/eprint/19014
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