Synergic synthesis of benzannulated zincabicyclic complexes, alpha-zincated n ylides, through sodium-TMEDA-mediated zincation of a haloarene
Armstrong, D.R. and Balloch, L. and Clegg, William and Dale, S.H. and Garcia-Alvarez, P. and Hevia, E. and Hogg, L.M. and Kennedy, A.R. and Mulvey, R.E. and O'Hara, Charles (2009) Synergic synthesis of benzannulated zincabicyclic complexes, alpha-zincated n ylides, through sodium-TMEDA-mediated zincation of a haloarene. Angewandte Chemie, 48 (46). pp. 8675-8678. ISSN 0044-8249
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Double role for sodium: Within a synergic sodium TMP-zincate reagent, sodium mediates the direct ortho-zincation of chlorobenzene and delivers the TMEDA ligand to nucleophilically attack the benzene ring, thereby generating novel open and cyclic zinc zwitterions (example shown). TMP=2,2,6,6-tetramethylpiperidide; TMEDA=N,N,N,N-tetramethylethylenediamine.
Creators(s): |
Armstrong, D.R., Balloch, L., Clegg, William, Dale, S.H., Garcia-Alvarez, P., Hevia, E. ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 18878 |
Keywords: | alkali metals, cooperative effects, metallacyclic compounds, metalation, zinc, Chemistry, Medicine(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Strathprints Administrator |
Date deposited: | 19 May 2010 10:54 |
Last modified: | 20 Jan 2021 18:38 |
URI: | https://strathprints.strath.ac.uk/id/eprint/18878 |
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