Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs
Pisani, Michelle J. and Wheate, N.J. and Keene, F. Richard and Aldrich-Wright, J.R. and Collins, J. Grant (2009) Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs. Journal of Inorganic Biochemistry, 103 (3). pp. 373-380. ISSN 0162-0134 (https://doi.org/10.1016/j.jinorgbio.2008.11.014)
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The use of anionic half-generation poly(amidoamine) dendrimers as drug delivery vehicles for [Pt(S,S-dach)(5,6-Me2phen)]2+ (56MESS) (where S,S-dach = 1S,2S-diaminocyclohexane; 5,6-Me2phen = 5,6-dimethyl-1,10-phenanthroline) and [{Δ,Δ-Ru(phen)2}2(μ-bb7)]4+ (Rubb7) (where phen = 1,10-phenanthroline; bb7 = 1,7-bis[4-(4′-methyl-2,2′-bipyridyl)heptane]) has been studied by nuclear magnetic resonance spectroscopy. From one- and two-dimensional 1H NMR spectra both 56MESS and Rubb7 were found to bind to the surface of generation 3.5, 4.5, 5.5 and 6.5 dendrimers through electrostatic interactions. The higher charge and larger size of Rubb7 resulted in stronger binding to all dendrimer generations (Kb 2 × 105 M−1) compared with 56MESS (Kb 1 × 104 M−1). Interestingly, there appeared to be no observable trend between dendrimer size and binding constant strength. The size of the free and 56MESS-bound dendrimers were examined using pulsed-gradient spin-echo NMR. The dendrimers ranged in hydrodynamic diameter from 11 to 20 nm and in all cases were larger than their corresponding full-generation dendrimer. Upon the addition of 56MESS the diameter of the dendrimers increased, consistent with surface binding.
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Item type: Article ID code: 18859 Dates: DateEvent2009PublishedSubjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > MicrobiologyDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Ms Ann Barker-Myles Date deposited: 17 May 2010 09:06 Last modified: 16 May 2024 22:05 URI: https://strathprints.strath.ac.uk/id/eprint/18859