Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles

McKenzie, Fiona and Faulds, K. and Graham, D. (2007) Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles. Small, 3 (11). pp. 1866-1868. ISSN 1613-6810

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Abstract

The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.