Picture of blood cells

Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

Explore the Open Access research of SIPBS. Or explore all of Strathclyde's Open Access research...

Synthesis, structural authentication, and structurally defined metalation reactions of lithium and sodium da-zincate bases (da = diisopropylamide) with phenylacetylene

Clegg, W. and Garcia-Alvarez, J. and Garcia-Alvarez, P. and Graham, D.V. and Harrington, R.W. and Hevia, E. and Kennedy, A.R. and Mulvey, R.E. (2008) Synthesis, structural authentication, and structurally defined metalation reactions of lithium and sodium da-zincate bases (da = diisopropylamide) with phenylacetylene. Organometallics, 27 (11). pp. 2654-2663. ISSN 0276-7333

Full text not available in this repository.Request a copy from the Strathclyde author

Abstract

In a study aimed at developing the diisopropylamido (DA) chemistry of zincates, the new lithium DA-zincate [(TMEDA)·Li(tBu)(DA)Zn(tBu)] (4) has been synthesized by an interlocking cocomplexation approach comprising mixing of its three component chemicals, LDA, tBu2Zn, and TMEDA, in a 1:1:1 ratio in hexane solution. Previously made by transamination from the corresponding TMP-zincate, the known sodium congener [(TMEDA)·Na(tBu)(DA)Zn(tBu)] (2) was also synthesized by this approach, substituting NaDA for LDA. Closely resembling each other, their molecular structures determined by X-ray crystallography can be categorized as contact ion-pair ates of TMEDA-chelated alkali metal cations linked to trigonal-planar dialkyl-Zn anions via bridging DA ligands. Reaction of 4 and 2 with phenylacetylene affords the bimetallic acetylides [{(TMEDA)·Li(CCPh)2Zn(tBu)}2·(TMEDA)] (5) and [{(TMEDA)·Na(CCPh)2Zn(tBu)}2 ] (6), respectively. X-ray crystallographic studies reveal 5 is a pseudodimer (tetranuclear) with two (LiCZnC) rings linked at the Zn atoms by a bridging, nonchelating TMEDA ligand; in contrast 6 adopts a distorted cubane of alternating PhCC and metal (2 Na, 2 Zn) corners. For comparison, the synthesis and crystal structures of the neutral zinc complexes [(TMEDA)·Zn(CCPh)2] (7) and [(TMEDA)·Zn(tBu)(CCPh)] (8), formally components of the ate complexes 5 and 6, are also reported. In addition, the 1H and 13C NMR spectra of 2, 4, 5, 6, 7, and 8 recorded from solutions in C6D6 are disclosed. (Abstract from: http://pubs.acs.org/doi/abs/10.1021/om8001813)