Metabolic profiling of lignan variability in Linum species of section Syllinum native to Bulgaria
Vasilev, Nikolay and Ebel, Rainer and Edrada-Ebel, RuAngelie and Fuss, Elizabeth and Alfermann, Wilhelm. A. and Ionkova, Illana and Petrova, Ana and Repplinger, Miriam and Schmidt, Thomas. J. (2008) Metabolic profiling of lignan variability in Linum species of section Syllinum native to Bulgaria. Planta Medica, 74 (3). pp. 273-280. ISSN 0032-0943
Full text not available in this repository.Request a copy from the Strathclyde authorAbstract
Lignans in eighteen samples of Linum species (L. tauricum ssp. tauricum, serbicum, bulgaricum and linearifolium; L. elegans; L. flavum ssp. sparsiflorum, L. capitatum var. laxiflorum), all members of the section Syllinum occurring in Bulgaria, were analysed by HPLC-ESI/MS and HPLC-UV/DAD. The ESI/MS fragmentation pathways recently established for aryltetralin lignans are now extended to ester and glycoside derivatives. In total, 22 different lignans, mainly of the aryltetralin type, were identified. 6-Methoxypodophyllotoxin and its glucoside were present as major constituents in all samples. Differences between the investigated taxa were observed especially with respect to the accumulation of 6-deoxy-7-hydroxy-aryltetralins such as podophyllotoxin and of 6-hydroxy-7-deoxy-aryltetralin lignans of the peltatin type. The distribution of aryltetralin lignans with different oxygenation patterns in the various samples, and correlations between the chemical data and the molecular phylogeny based on an analysis of ITS sequences of the investigated species are discussed.
| Author(s): | Vasilev, Nikolay, Ebel, Rainer, Edrada-Ebel, RuAngelie, Fuss, Elizabeth, Alfermann, Wilhelm. A., Ionkova, Illana, Petrova, Ana, Repplinger, Miriam and Schmidt, Thomas. J. | Item type: | Article |
|---|---|
| ID code: | 15322 |
| Keywords: | aryltetralin lignan, HPLC-ESI/MS, HPLC-UV/DAD, linum L., linaceae, chemical and molecular systematics, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Ms Ann Barker-Myles |
| Date deposited: | 04 Feb 2010 15:49 |
| Last modified: | 03 Jan 2019 12:05 |
| Related URLs: | |
| URI: | https://strathprints.strath.ac.uk/id/eprint/15322 |
| Export data: |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)