A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function
Whalley, H C and Pickard, B S and McIntosh, A M and Zuliani, R and Johnstone, E C and Blackwood, D H R and Lawrie, S M and Muir, W J and Hall, J (2009) A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function. Molecular Psychiatry, 14 (5). pp. 467-468. ISSN 1359-4184 (https://doi.org/10.1038/mp.2009.7)
Full text not available in this repository.Request a copyAbstract
The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.
ORCID iDs
Whalley, H C, Pickard, B S ORCID: https://orcid.org/0000-0002-2374-6329, McIntosh, A M, Zuliani, R, Johnstone, E C, Blackwood, D H R, Lawrie, S M, Muir, W J and Hall, J;-
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Item type: Article ID code: 12934 Dates: DateEventMay 2009PublishedSubjects: Medicine > Pharmacy and materia medica
Science > MicrobiologyDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Mr Scott Kilgariff Date deposited: 24 Aug 2009 12:56 Last modified: 06 Sep 2024 05:32 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/12934