Two new paracetamol / dioxane solvates - a system exhibiting a reversible solid state phase transformation

Vrcelj, R.M. and Clark, Nathan I.B. and Kennedy, A.R. and Sheen, D.B. and Shepherd, E.E.A. and Sherwood, J.N. (2003) Two new paracetamol / dioxane solvates - a system exhibiting a reversible solid state phase transformation. Journal of Pharmaceutical Sciences, 92 (10). pp. 2069-2073. ISSN 0022-3549 (http://dx.doi.org/10.1002/jps.10477)

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Abstract

This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z = 8, a = 12.6078(3) î.., b = 12.1129(2) î.., c = 13.4138(3) î.., V = 2048.52(7) î..3, (at 295 K) and the low temperature form is monoclinic, space group P21/c, Z = 4, a = 12.325(6) î.., b = 11.965(4) î.., c = 13.384(6) î.., = 92.01°, V = 1972.6(14)î..3 (at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol.

ORCID iDs

Vrcelj, R.M., Clark, Nathan I.B., Kennedy, A.R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Sheen, D.B., Shepherd, E.E.A. and Sherwood, J.N.;
  • Item type:Article
    ID code:1087
    Dates:
    Date
    Event
    29 July 2003
    Published
    Keywords:crystallization, crystallography, polymorphism, solvate, Chemistry, Pharmaceutical Science
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Catriona Mccallum
    Date deposited:19 May 2006
    Last modified:20 Jan 2021 16:54
    URI:https://strathprints.strath.ac.uk/id/eprint/1087
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