Chiral analysis of methylphenidate and dextromoramide by capillary electrophoresis

Denk, Oliver M. and Watson, D.G. and Skellern, G.G. (2001) Chiral analysis of methylphenidate and dextromoramide by capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications, 761 (1). pp. 61-68. ISSN 1387-2273

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Official URL: https://doi.org/10.1016/S0378-4347(01)00300-0

Abstract

Capillary electrophoretic methods have been developed to separate the enantiomers of methylphenidate (MPH) and dextromoramide. For MPH separation was achieved with heptakis (2,6-di-O-methyl)-beta -cyclodextrin (DMCD) as chiral selector in a 100 mM phosphoric acid buffer adjusted to pH 3.0 with triethanolamine. Commercial samples Of D,L-erytho-MPH HCl and D,L-threo-MPH HCl were analysed using the method. There was no evidence of the presence of D,L-threo-MPH HCl in D,L-etytho-MPH HCl and vice versa. The ratio of the enantiomers was determined for each diasteroisomer. Hydroxypropyl-beta -cyclodextrin was the chiral selector of choice for the chiral separation of the enantiomers of moramide. The separation which gave a resolution of about 3.5 was achieved in 4 min using only a 6 cm of length of capillary. In a sample of dextro-R-moramide tartrate only a small quantity (4.9% w/w) of levo-S-moramide was detected with this method.

Author(s):	Denk, Oliver M., Watson, D.G. ORCID: https://orcid.org/0000-0003-1094-7604 and Skellern, G.G.
Item type:	Article
ID code:	10600
Keywords:	enantiomer separation, methylphenidate, dextromoramide, Pharmacy and materia medica, Chemistry(all)
Subjects:	Medicine > Pharmacy and materia medica
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user:	Strathprints Administrator
Date deposited:	21 Apr 2011 04:04
Last modified:	20 Jan 2020 17:05
URI:	https://strathprints.strath.ac.uk/id/eprint/10600
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