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Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Number of items: 33.

Keune, Willem-Jan and Potjewyd, Frances and Heidebrecht, Tatjana and Salgado-Polo, Fernando and Macdonald, Simon J. F. and Chelvarajan, Lakshman and Abdel Latif, Ahmed and Soman, Sony and Morris, Andrew J. and Watson, Allan J. B. and Jamieson, Craig and Perrakis, Anastassis (2017) Rational design of autotaxin inhibitors by structural evolution of endogenous modulators. Journal of Medicinal Chemistry, 60 (5). pp. 2006-2017. ISSN 0022-2623

Miller, Lisa M. and Pritchard, John M. and Macdonald, Simon J. F. and Jamieson, Craig and Watson, Allan J. B. (2017) Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins. Journal of Medicinal Chemistry, 60 (8). ISSN 0022-2623

Miller, Lisa M. and Keune, Willem-Jan and Castagna, Diana and Young, Louise C. and Duffy, Emma L. and Potjewyd, Frances and Salgado-Polo, Fernando and Garcia, Paloma Engel and Semaan, Dima and Pritchard, John M. and Perrakis, Anastassis and Macdonald, Simon J. F. and Jamieson, Craig and Watson, Allan J. B. (2017) Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode. Journal of Medicinal Chemistry, 60 (2). pp. 722-748. ISSN 0022-2623

Amour, Augustin and Barton, Nick and Cooper, Anthony W.J. and Inglis, Graham and Jamieson, Craig and Luscombe, Christopher N. and Perez, David and Peace, Simon and Rowland, Paul and Tame, Chris and Uddin, Sorif and Vitulli, Giovanni and Wellaway, Natalie (2016) Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease. Journal of Medicinal Chemistry. ISSN 0022-2623

Borthwick, Jennifer A. and Ancellin, Nicolas and Bertrand, Sophie M. and Bingham, Ryan P. and Carter, Paul S. and Chung, Chun-wa and Churcher, Ian and Dodic, Nerina and Fournier, Charlène and Francis, Peter L. and Hobbs, Andrew and Jamieson, Craig and Pickett, Stephen D. and Smith, Sarah E. and Somers, Donald O'N. and Spitzfaden, Claus and Suckling, Colin J. and Young, Robert J. (2016) Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening. Journal of Medicinal Chemistry, 59 (6). pp. 2452-2467. ISSN 0022-2623

Westaway, Susan M. and Preston, Alex G. S. and Barker, Michael D. and Brown, Fiona and Brown, Jack A. and Campbell, Matthew and Chung, Chun-Wa and Drewes, Gerard and Eagle, Robert and Garton, Neil and Gordon, Laurie and Haslam, Carl and Hayhow, Thomas G. and Humphreys, Philip G. and Joberty, Gerard and Katso, Roy and Kruidenier, Laurens and Leveridge, Melanie and Pemberton, Michelle and Rioja, Inma and Seal, Gail A. and Shipley, Tracy and Singh, Onkar and Suckling, Colin J. and Taylor, Joanna and Thomas, Pamela and Wilson, David M. and Lee, Kevin and Prinjha, Rab K. (2016) Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives. Journal of Medicinal Chemistry, 59 (4). pp. 1370-1387. ISSN 0022-2623

Theodoulou, Natalie H. and Bamborough, Paul and Bannister, Andrew J. and Becher, Isabelle and Bit, Rino A. and Che, Ka Hing and Chung, Chun-wa and Dittmann, Antje and Drewes, Gerard and Drewy, David H. and Gordon, Laurie and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Michon, Anne-Marie and Molnar, Judit and Robson, Samuel C. and Tomkinson, Nicholas C. O. and Kouzarides, Tony and Prinjha, Rab K. and Humphreys, Philip G. (2016) The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. Journal of Medicinal Chemistry, 59 (4). pp. 1425-1439. ISSN 0022-2623

Zmuda, Filip and Malviya, Gaurav and Blair, Adele and Boyd, Marie and Chalmers, Anthony J. and Sutherland, Andrew and Pimlott, Sally L. (2015) Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo. Journal of Medicinal Chemistry, 58 (21). pp. 8683-8693. ISSN 0022-2623

Bertrand, Sophie M. and Ancellin, Nicolas and Beaufils, Benjamin and Bingham, Ryan P. and Borthwick, Jennifer A. and Boullay, Anne Bénédicte and Boursier, Eric and Carter, Paul S. and Chung, Chun Wa and Churcher, Ian and Dodic, Nerina and Fouchet, Marie Hélène and Fournier, Charlène and Francis, Peter L. and Gummer, Laura A. and Herry, Kenny and Hobbs, Andrew and Hobbs, Clare I. and Homes, Paul and Jamieson, Craig and Nicodeme, Edwige and Pickett, Stephen D. and Reid, Iain H. and Simpson, Graham L. and Sloan, Lisa A. and Smith, Sarah E. and Somers, Donald O N and Spitzfaden, Claus and Suckling, Colin J. and Valko, Klara and Washio, Yoshiaki and Young, Robert J. (2015) The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits. Journal of Medicinal Chemistry, 58 (18). pp. 7140-7163. ISSN 0022-2623

Khalaf, Abedawn I and Huggan, Judith and Suckling, Colin J and Gibson, Colin L and Stewart, Kirsten and Giordani, Federica and Barrett, Michael P. and Wong, Pui Ee and Barrack, Keri L and Hunter, William N (2014) Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57 (15). pp. 6479-6494. ISSN 0022-2623

Baek, Dong Jae and MacRitchie, Neil and Anthony, Nahoum G and Mackay, Simon P and Pyne, Susan and Pyne, Nigel J and Bittman, Robert (2013) Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry, 56 (22). pp. 9310-9327. ISSN 0022-2623

Talapatra, Sandeep K. and Anthony, Nahoum Guillaume Hsuan and MacKay, Simon and Kozielski, Frank (2013) The mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. Journal of Medicinal Chemistry, 56 (16). pp. 6317-6329. ISSN 0022-2623

Trump, Ryan P. and Bresciani, Stefano and Cooper, Anthony W. J. and Tellam, James P. and Wojno, Justyna and Blaikley, John and Orband-Miller, Lisa A. and Kashatus, Jennifer A. and Boudjelal, Mohamed and Dawson, Helen C. and Loudon, Andrew and Ray, David and Grant, Daniel and Farrow, Stuart N. and Willson, Timothy M. and Tomkinson, Nicholas C. O. (2013) Optimized chemical probes for REV-ERB alpha. Journal of Medicinal Chemistry, 56 (11). pp. 4729-4737. ISSN 0022-2623

Good, James A. D. and Wang, Fang and Rath, Oliver and Kaan, Hung Yi Kristal and Talapatra, Sandeep K. and Podgorski, Dawid and MacKay, Simon P. and Kozielski, Frank (2013) Optimized s-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. Journal of Medicinal Chemistry, 56 (5). pp. 1878-1893. ISSN 0022-2623

Viswanath, AN and Pae, AN and MacKay, Simon (2013) Resistance by allostery: a novel perspective for Eg5-targeted drug design. Journal of Medicinal Chemistry. ISSN 0022-2623

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Rodgers, David and Harnett, Margaret and Harnett, William and Scott, Fraser (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis : Helminth-based synthetic compound protects against CIA. Journal of Medicinal Chemistry, 56. pp. 9982-10002. ISSN 0022-2623

Fomovska, Alina and Wood, Richard and Mui, E. and Dubey, J.P. and Ferreira, Leandra and Hickman, Mark and Lee, Patricia and Leed, Susan and Auschwitz, Jennifer and Welsh, William and Sommerville, Caroline and Woods, Stuart and Roberts, Craig and Mcleod, Rima (2012) Salicylanilide inhibitors of toxoplasma gondii. Journal of Medicinal Chemistry, 55 (19). pp. 8375-8391. ISSN 0022-2623

Wang, F. and Good, J. A. D. and Rath, O. and Kaan, H. Y. K. and Sutcliffe, O. B. and Mackay, S. P. and Kozielski, F. (2012) Triphenylbutanamines : kinesin spindle protein inhibitors with in vivo antitumor activity. Journal of Medicinal Chemistry, 55 (4). pp. 1511-1525. ISSN 0022-2623

Dover, Lynn G. and Coxon, Geoffrey (2011) Currrent status and research strategies in tuberculosis drug development. Journal of Medicinal Chemistry, 54 (18). 6157–6165. ISSN 0022-2623

Tulloch, Lindsay B. and Martini, Viviane P. and Iulek, Jorge and Huggan, J. and Lee, Jeong Hwan and Gibson, C.L. and Smith, Terry K. and Suckling, C.J. and Hunter, William N. (2010) Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. Journal of Medicinal Chemistry, 53 (1). pp. 221-229. ISSN 0022-2623

Grove, Simon J.A. and Jamieson, Craig and Maclean, John K.F. and Morrow, John A. and Rankovic, Zoran (2010) Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Journal of Medicinal Chemistry, 53 (20). pp. 7271-7279. ISSN 0022-2623

Tipparaju, Suresh K and Muench, Stephen P and Mui, Ernest J and Ruzheinikov, Sergey N and Lu, Jeffrey Z. and Hutson, Samuel L and Kirisits, Michael J. and Prigge, Sean T. and Roberts, Craig and Henriquez, Fiona L and Kozikowski, Alan P and Rice, David W and McLeod, Rima L (2010) Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. Journal of Medicinal Chemistry, 53 (17). pp. 6287-6300.

Coxon, Geoffrey D. and Furman, Brian L. and Harvey, Alan L. and McTavish, John and Mooney, Mark H. and Arastoo, Mahmoud and Kennedy, A.R. and Tettey, J.N.A. and Waigh, R.D. (2009) Benzylguanidines and other galegine analogues inducing weight loss in mice. Journal of Medicinal Chemistry, 52 (11). pp. 3457-3463. ISSN 0022-2623

Krause-Heuer, A.M. and Grunert, R. and Kuhne, S. and Maruszak, M. and Wheate, N.J. and Le Pevelen, D. and Boag, L.R. and Fisher, D.M. (2009) Studies into the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells. Journal of Medicinal Chemistry, 52 (17). pp. 5474-5484. ISSN 0022-2623

Kemp, S. and Wheate, N.J. and Pisani, Michelle J. and Aldrich-Wright, J.R. (2008) Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced l-glutathione. Journal of Medicinal Chemistry, 51 (9). pp. 2787-2794. ISSN 0022-2623

Anthony, Nahoum Guillaume Hsuan and Breen, D. and Clarke, Joanna and Donoghue, Gavin and Drummond, Allan J. and Ellis, Elizabeth and Gemmell, Curtis G. and Helesbeux, Jean-Jacques and Hunter, Iain. S. and Khalaf, Abedawn and MacKay, Simon and Parkinson, J.A. and Suckling, C.J. and Waigh, R.D. (2007) Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. Journal of Medicinal Chemistry, 50 (24). pp. 6116-6125. ISSN 0022-2623

Woo, L.W.L. and Bubert, C. and Sutcliffe, O.B. and Smith, A. and Chander, S.K. and Mahon, M.F. and Purohit, A. and Reed, M.J. and Potter, B.V.L. (2007) Dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 50 (15). pp. 3540-3560. ISSN 0022-2623

Habtemariam, Abraha and Melchart, Michael and Fernandez, Rafael and Parsons, Simon and Oswald, Iain D. H. and Parkin, Andrew and Fabbiani, Francesca P. A. and Davidson, James E. and Dawson, Alice and Aird, Rhona E. and Jodrell, Duncan I. and Sadler, Peter J. (2006) Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry, 49 (23). pp. 6858-6868. ISSN 0022-2623

Corea, G. and Fattorusso, E. and Lanzotti, V. and Di Meglio, P. and Maffia, P. and Grassia, G. and Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48 (22). pp. 7055-7062. ISSN 0022-2623

Khalaf, A.I. and Waigh, R.D. and Drummond, A.J. and Pringle, B. and McGroarty, I. and Skellern, G.G. and Suckling, C.J. (2004) Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity. Journal of Medicinal Chemistry, 47 (8). pp. 2133-2156. ISSN 0022-2623

Woo, L.W.L. and Sutcliffe, O.B. and Bubert, C. and Grasso, A. and Chander, S.K. and Purohit, A. and Reed, M.J. and Potter, B.V.L. (2003) First dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 46 (15). pp. 3193-3196. ISSN 0022-2623

Khalaf, A.I. and Pitt, A.R. and Scobie, M. and Suckling, C.J. and Urwin, J. and Waigh, R.D. and Young, S.C. and Fishleigh, R.V. and Fox, K.R. (2000) DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins. Journal of Medicinal Chemistry, 43 (17). pp. 3257-3266. ISSN 0022-2623

McKenna, M T and Proctor, G R and Young, L C and Harvey, A L (1997) Novel tacrine analogues for potential use against Alzheimer's disease : potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of Medicinal Chemistry, 40 (22). pp. 3516-3523. ISSN 0022-2623

This list was generated on Sun Jun 25 23:51:26 2017 BST.