|Up a level|
Gallagher, Laura E. and Williamson, Leon E. and Chan, Edmond Y. W. (2016) Advances in autophagy regulatory mechanisms. Cells, 5 (2). ISSN 2073-4409
Karvela, Maria and Baquero, Pablo and Kuntz, Elodie M. and Mukhopadhyay, Arunima and Mitchell, Rebecca and Allan, Elaine K. and Chan, Edmond and Kranc, Kamil R. and Calabretta, Bruno and Salomoni, Paolo and Gottlieb, Eyal and Holyoake, Tessa L. and Vignir Helgason, G. (2016) ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells. Autophagy. ISSN 1554-8627
Watson, David G and Tonelli, Francesca and Al Osaimi, Manal and Williamson, Leon and Chan, Edmond and Gorshkova, Irina and Berdyshev, Evgeny and Bittman, Robert and Pyne, Nigel J and Pyne, Susan (2013) The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cellular Signalling, 25 (4). pp. 1011-1017. ISSN 1873-3913
Tonelli, F. and Alossaimi, M. and Williamson, L. and Tate, R.J. and Watson, D.G. and Chan, E. and Bittman, R. and Pyne, N.J. and Pyne, S. (2013) The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. British Journal of Pharmacology, 168 (6). pp. 1497-1505. ISSN 1476-5381
McAlpine, Fiona and Williamson, Leon E and Tooze, Sharon A and Chan, Edmond Y W (2013) Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy, 9 (3). 361 - 373.
Mleczak, Andrzej and Millar, Sarah and Tooze, Sharon A and Olson, Michael F and Chan, Edmond Y W (2013) Regulation of autophagosome formation by Rho kinase. Cellular Signalling, 25 (1). pp. 1-11. ISSN 1873-3913
Gallagher, Laura E and Chan, Edmond Y W (2013) Early signalling events of autophagy. Essays in Biochemistry, 55. pp. 1-15. ISSN 1744-1358
Chan, Edmond Y (2012) Regulation and function of uncoordinated-51 like kinase proteins. Antioxidants and Redox Signaling, 17 (5). pp. 775-785. ISSN 1557-7716
Klionsky, Daniel J. and Abdalla, Fabio C. and Abeliovich, Hagai and Abraham, Robert T. and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agnello, Maria and Al-Zeer, Munir A. and Chan, Edmond and Coombs, Graham and Menzies, Fiona Mary and Mottram, Jeremy (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8 (4). pp. 445-544. ISSN 1554-8627
Chan, Edmond Y (2009) mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. Science signaling, 2 (84). pe51.
Chan, Edmond Y. and Tooze, Sharon A. (2009) Evolution of Atg1 function and regulation. Autophagy, 5 (6). pp. 758-765.
Razi, M. and Chan, Edmond Y. and Tooze, Sharon A. (2009) Early endosomes and endosomal coatomer are required for autophagy. Journal of Cell Biology, 185 (2). pp. 305-321. ISSN 0021-9525
Chan, Edmond Y. and Longatti, Andrea and McKnight, Nicole C. and Tooze, Sharon A. (2009) Kinase-inactivated ULK proteins inhibit autophagy via their conserved c-terminal domains using an Atg13-independent mechanism. Molecular and Cellular Biology, 29 (1). pp. 157-171. ISSN 0270-7306
Chan, Edmond Y W and Kir, Serkan and Tooze, Sharon A (2007) siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. Journal of Biological Chemistry, 282 (35). pp. 25464-25474. ISSN 1083-351X
Young, Andrew R.J. and Chan, Edmond Y W and Hu, Xiao Wen and Köchl, Robert and Crawshaw, Samuel G and High, Stephen and Hailey, Dale W and Lippincott-Schwartz, Jennifer and Tooze, Sharon A. (2006) Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. Journal of Cell Science, 119 (18). pp. 3888-3900. ISSN 0021-9533
Köchl, Robert and Hu, Xiao Wen and Chan, Edmond Y W and Tooze, Sharon A (2006) Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic, 7 (2). pp. 129-145. ISSN 1398-9219
Warby, Simon C and Chan, Edmond Y and Metzler, Martina and Gan, Lu and Singaraja, Roshni R and Crocker, Susan F and Robertson, Harold A and Hayden, Michael R (2005) Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Human Molecular Genetics, 14 (11). pp. 1569-1577. ISSN 0964-6906
Tang, Tie-Shan and Tu, Huiping and Orban, Paul C and Chan, Edmond Y W and Hayden, Michael R and Bezprozvanny, Ilya (2004) HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons. European Journal of Neuroscience, 20 (7). 1779–1787. ISSN 0953-816X
Tang, Tie-Shan and Tu, Huiping and Chan, Edmond Y W and Maximov, Anton and Wang, Zhengnan and Wellington, Cheryl L and Hayden, Michael R and Bezprozvanny, Ilya (2003) Huntingtin and Huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron, 39 (2). pp. 227-239. ISSN 0896-6273
Chan, E Y W (2002) HIP1 as a marker of aggressive prostate cancer. Clinical Genetics, 62 (5). pp. 372-375. ISSN 0009-9163
Luthi-Carter, Ruth and Hanson, Sarah A and Strand, Andrew D and Bergstrom, Donald A and Chun, Wanjoo and Peters, Nikki L and Woods, Annette M and Chan, Edmond Y and Kooperberg, Charles and Krainc, Dimitri and Young, Anne B and Tapscott, Stephen J and Olson, James M (2002) Dysregulation of gene expression in the R6/2 model of polyglutamine disease : parallel changes in muscle and brain. Human Molecular Genetics, 11 (17). pp. 1911-1926. ISSN 0964-6906
Chan, Edmond Y W and Luthi-Carter, Ruth and Strand, Andrew and Solano, Steven M and Hanson, Sarah A and DeJohn, Molly M and Kooperberg, Charles and Chase, Kathryn O and DiFiglia, Marian and Young, Anne B and Leavitt, Blair R and Cha, Jang-Ho J and Aronin, Neil and Hayden, Michael R and Olson, James M (2002) Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. Human Molecular Genetics, 11 (17). pp. 1939-1951. ISSN 0964-6906
Chan, Edmond Y W and Nasir, Jamal and Gutekunst, Claire-Anne and Coleman, Sarah and Maclean, Alan and Maas, Alex and Metzler, Martina and Gertsenstein, Marina and Ross, Christopher A and Nagy, Andràs and Hayden, Michael R (2002) Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Human Molecular Genetics, 11 (8). pp. 945-959. ISSN 0964-6906
Chan, Edmond Y W and Stang, Stacey L and Bottorff, Drell A and Stone, James C (2002) Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity. Molecular Carcinogenesis, 33 (4). pp. 189-97. ISSN 0899-1987
Chan, E Y and Stang, S L and Bottorff, D A and Stone, J C (1999) Hypothermic stress leads to activation of Ras-Erk signaling. Journal of Clinical Investigation, 103 (9). pp. 1337-44. ISSN 0021-9738
Ebinu, J O and Bottorff, D A and Chan, E Y and Stang, S L and Dunn, R J and Stone, J C (1998) RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science, 280 (5366). pp. 1082-1086. ISSN 0036-8075
Rusiñol, A E and Chan, E Y and Vance, J E (1993) Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine. Journal of Biological Chemistry, 268 (33). pp. 25168-75. ISSN 1083-351X
Conference or Workshop Item
Lima, Ana and Braidwood, Lynne and Learmonth, Kirsty and Chan, Edmond and Conner, Joe (2014) Autophagy in human cancer cell lines during infection with the ICP34.5-deleted oncolytic HSV1716. In: 8th International Conference on Oncolytic Virus Therapeutics, 2014-04-10 - 2014-04-13.