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Number of items: 64.

Storm, Janet and Sethia, Sonal and Blackburn, Gavin and Chokkathukalam, A and Watson, David and Breitling, R. and Coombs, Graham and Muller, S. (2014) Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism. PLoS Pathogens, 10 (1). pp. 1-14. ISSN 1553-7366

Proto, William R and Jones, N.G. and Coombs, Graham and Mottram, Jeremy (2014) Tracking autophagy during proliferation and differentiation of Trypanosoma brucei. Microbial Cell, 1 (1). pp. 9-20.

Judice, W.A.S. and Manfredi, Marcella A and Souza, Gerson A. and Sansevero, Thiago M. and Almeida, Paulo C and Shida, Claudio S. and Gesteira, Tarsis F. and Juliano, Luiz and Westrop, Gareth and Sanderson, Sanya J and Coombs, Graham and Tersariol, Ivarne L.S. (2013) Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8. PLOS One, 8 (11). ISSN 1932-6203

Schröder, Jörg and Noack, Sandra and Marhöfer, Richard J and Mottram, Jeremy C and Coombs, Graham H and Selzer, Paul M (2013) Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB. PLOS One, 8 (10).

Tomlins, Andrew M and Ben-Rached, Fathia and Williams, Roderick Am and Proto, William R and Coppens, Isabelle and Ruch, Ulrike and Gilberger, Tim W and Coombs, Graham H and Mottram, Jeremy C and Müller, Sylke and Langsley, Gordon (2013) Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. Autophagy, 9 (10). 1540 - 1552.

Williams, Roderick A M and Mottram, Jeremy C and Coombs, Graham H (2013) Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major. Journal of Biological Chemistry, 288 (5). pp. 3678-3690.

Proto, William R and Coombs, Graham and Mottram, Jeremy (2013) Cell death in parasitic protozoa : regulated or incidental? Nature Reviews Microbiology, 11. pp. 58-66. ISSN 1740-1526

Fyfe, Paul K and Westrop, Gareth D and Silva, Ana Marta and Coombs, Graham H and Hunter, William N (2012) Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proceedings of the National Academy of Sciences, 109 (29). pp. 11693-11698.

Fyfe, Paul K and Westrop, Gareth D and Ramos, Tania and Müller, Sylke and Coombs, Graham H and Hunter, William N (2012) Structure of Leishmania major cysteine synthase. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68 (7). pp. 738-743.

Alsaadi, Manal and Italia, Jagdishbhai Laxmanbhai and Mullen, Alexander and Kumar, M.N.V Ravi and Candlish, A.A. and Williams, Roderick and Shaw, C.D. and Al-Gawhari, Fatima and Coombs, Graham and Wiese, Martin and Thomson, Alison and Puig-Sellart, M. and Wallace, J. and Sharp, A and Wheeler, Lee and Warn, Peter and Carter, Katharine (2012) The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection. Journal of Controlled Release, 160 (3). pp. 685-691. ISSN 0168-3659

Silva, A M and Tavares, J and Silvestre, R and Ouaissi, A and Coombs, Graham and Cordeiro-da-Silva, A (2012) Characterization of Leishmania infantum thiol-dependent reductase 1 and evaluation of its potential to induce immune protection. Parasite Immunology, 34 (6). pp. 345-350.

Williams, Roderick A M and Smith, Terry K and Cull, Benjamin and Mottram, Jeremy C and Coombs, Graham H (2012) ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS Pathogens, 8 (5).

McLuskey, Karen and Rudolf, Jana and Proto, William R and Isaacs, Neil W and Coombs, Graham H and Moss, Catherine X and Mottram, Jeremy C (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences, 109 (19). pp. 7469-7474.

Klionsky, Daniel J. and Abdalla, Fabio C. and Abeliovich, Hagai and Abraham, Robert T. and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agnello, Maria and Al-Zeer, Munir A. and Chan, Edmond and Coombs, Graham and Menzies, Fiona Mary and Mottram, Jeremy (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8 (4). pp. 445-544. ISSN 1554-8627

Decuypere, Saskia and Vanaerschot, Manu and Brunker, Kirstyn and Imamura, Hideo and Müller, Sylke and Khanal, Basudha and Rijal, Suman and Dujardin, Jean-Claude and Coombs, Graham H (2012) Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background. PLoS Neglected Tropical Diseases, 6 (2).

Morrison, Lesley S and Goundry, Amy and Faria, Marilia S and Tetley, Laurence and Eschenlauer, Sylvain C and Westrop, Gareth D and Dostalova, Anna and Volf, Petr and Coombs, Graham H and Lima, Ana Paula C A and Mottram, Jeremy C (2012) Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. Cellular Microbiology. (In Press)

Castanys-Muñoz, E and Brown, E and Coombs, Graham and Mottram, J C (2012) Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells. Cell Death and Disease, 3. ISSN 2041-4889

Silva, Ana Marta and Cordeiro-da-Silva, Anabela and Coombs, Graham H (2011) Metabolic variation during development in culture of Leishmania donovani promastigotes. PLoS Neglected Tropical Diseases, 5 (12). pp. 1-13.

Downing, Tim and Imamura, Hideo and Decuypere, Saskia and Clark, Taane G and Coombs, Graham H and Cotton, James A and Hilley, James D and de Doncker, Simonne and Maes, Ilse and Mottram, Jeremy C and Quail, Mike A and Rijal, Suman and Sanders, Mandy and Schönian, Gabriele and Stark, Olivia and Sundar, Shyam and Vanaerschot, Manu and Hertz-Fowler, Christiane and Dujardin, Jean-Claude and Berriman, Matthew (2011) Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Research, 21 (12). pp. 2143-2156. ISSN 1088-9051

Albalat, A. and Gornik, S. G. and Mullen, W. and Crozier, Alan and Atkinson, R. J. A. and Coombs, Graham and Neil, D. M. (2011) Quality changes in chilled Norway lobster (Nephrops norvegicus) tail meat and the effects of delayed icing. International Journal of Food Science and Technology, 46 (7). pp. 1413-1421. ISSN 0950-5423

Moya, Ignace A and Westrop, Gareth D and Coombs, Graham H and Honek, John F (2011) Mechanistic studies on the enzymatic processing of fluorinated methionine analogs by Trichomonas vaginalis methionine γ-lyase. Biochemical Journal.

t'Kindt, Ruben and Jankevics, Andris and Scheltema, Richard A. and Zheng, Liang and Watson, David G. and Dujardin, Jean-Claude and Breitling, Rainer and Coombs, Graham H. and Decuypere, Saskia (2011) Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis (vol 398, pg 2059, 2010). Analytical and bioanalytical chemistry, 400 (2). p. 635. ISSN 1618-2642

Duszenko, Michael and Ginger, Michael L. and Brennand, Ana and Gualdrón-López, Melisa and Colombo, María Isabel and Coombs, Graham H and Coppens, Isabelle and Jayabalasingham, Bamini and Langsley, Gordon and de Castro, Solange Lisboa and Menna-Barreto, Rubem and Mottram, Jeremy C and Navarro, Miguel and Rigden, Daniel J. and Romano, Patricia S. and Stoka, Veronika and Turk, Boris and Michels, Paul A.M. (2011) Autophagy in protists. Autophagy, 7 (2). pp. 127-158.

Munday, Jane C. and McLuskey, Karen and Brown, Elaine and Coombs, Graham H and Mottram, Jeremy C (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175 (1). pp. 49-57. ISSN 0166-6851

Schaeffer, Marie and Schroeder, Joerg and Heckeroth, Anja R and Noack, Sandra and Gassel, Michael and Mottram, Jeremy C and Selzer, Paul M and Coombs, Graham H (2011) Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella. Antimicrobial Agents and Chemotherapy. ISSN 1098-6596

Ambit, Audrey and Woods, Kerry L and Cull, Benjamin and Coombs, Graham H and Mottram, Jeremy C (2011) Morphological events during the cell cycle of Leishmania major. Eukaryotic Cell.

Proto, William R and Castanys-Munoz, Esther and Black, Alana and Tetley, Laurence and Moss, Catherine X and Juliano, Luiz and Coombs, Graham H and Mottram, Jeremy C (2011) Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. Journal of Biological Chemistry. ISSN 1083-351X

t'Kindt, Ruben and Scheltema, Richard A and Jankevics, Andris and Brunker, Kirstyn and Rijal, Suman and Dujardin, Jean-Claude and Breitling, Rainer and Watson, David G and Coombs, Graham H and Decuypere, Saskia (2010) Metabolomics to unveil and understand phenotypic diversity between pathogen populations. PLoS Neglected Tropical Diseases, 4 (11). ISSN 1935-2727

Steert, Koen and Berg, Maya and Mottram, Jeremy C. and Westrop, Gareth D. and Coombs, Graham H. and Cos, Paul and Maes, Louis and Joossens, Jurgen and Van der Veken, Pieter and Haemers, Achiel and Augustyns, Koen (2010) alpha-Ketoheterocycles as inhibitors of leishmania mexicana cysteine protease CPB. ChemMedChem, 5 (10). pp. 1734-1748. ISSN 1860-7179

Coombs, Graham H. (2010) Insights into the metabolomes of parasites. Parasitology, 137 (Special Issue 9). p. 1283. ISSN 0031-1820

Scheltema, Richard A. and Decuypere, Saskia and T'Kindt, Ruben and Dujardin, Jean-Claude and Coombs, Graham H. and Breitling, Rainer (2010) The potential of metabolomics for Leishmania research in the post-genomics era. Parasitology, 137 (9). pp. 1291-1302. ISSN 0031-1820

Zheng, Liang and T'Kind, Ruben and Decuypere, Saskia and von Freyend, Simona John and Coombs, Graham H. and Watson, David G. (2010) Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. Rapid Communications in Mass Spectrometry, 24 (14). pp. 2074-2082. ISSN 0951-4198

Berg, M. and van der Veken, P. and Joossens, J. and Muthusamy, V. and Breugelmans, M. and Moss, C.X. and Rudolf, J. and Coombs, G.H. (2010) Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (6). pp. 2001-2006. ISSN 0960-894X

Gornik, Sebastian G. and Albalat, Amaya and Atkinson, Robert J. A. and Coombs, Graham H. and Neil, Douglas M. (2010) The influence of defined ante-mortem stressors on the early post-mortem biochemical processes in the abdominal muscle of the Norway lobster, Nephrops norvegicus (Linnaeus, 1758). Marine Biology Research, 6 (3). pp. 223-238. ISSN 1745-1000

Westrop, G.D. and Georg, I. and Coombs, G.H. (2009) The mercaptopyruvate sulfurtransferase of trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. Journal of Biological Chemistry, 284 (48). pp. 33485-33494. ISSN Print ISSN 0021-9258; Online ISSN 1083-351X

Bryson, K.J. and Besteiro, Sébastien and McGachy, H.A. and Coombs, G.H. and Mottram, J.C. and Alexander, J. (2009) Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity, 77 (7). pp. 2971-2978. ISSN 0019-9567

Williams, Roderick A.M. and Westrop, Gareth D. and Coombs, G.H. (2009) Two pathways for cysteine biosynthesis in Leishmania major. Biochemical Journal, 420. pp. 451-462. ISSN 0264-6021

Williams, Roderick and Woods, K.L. and Juliano, L. and Mottram, J.C. and Coombs, G.H. (2009) Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy, 5 (2). pp. 159-172.

McMillan, P.J. and Patzewitz, E.M. and Young, S.E. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2009) Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets. Parasitology, 136 (1). pp. 27-33. ISSN 0031-1820

Albalat, A. and Gornik, S.G. and Atkinson, R.J.A. and Coombs, G.H. and Neil, D.M. (2009) Effect of capture method on the physiology and nucleotide breakdown products in the Norway lobster (nephrops norvegicus). Marine Biology Research, 5 (5). pp. 441-450. ISSN 1745-1000

Jecna, Lucie and Svarovska, Anna and Besteiro, Sébastien and Mottram, Jeremy C. and Coombs, Graham H. and Volf, Petr (2009) Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. Journal of Entomology, 46 (3). pp. 605-609. ISSN 0022-2585

Gornik, S.G. and Westrop, G.D. and Coombs, G.H. and Neil, D.M. (2009) Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus. Molecular Biology Reports, 37 (4). pp. 2009-2019. ISSN 0301-4851

Richardson, Julia M. and Morrison, Lesley S. and Bland, Nicholas D. and Bruce, Sandra and Coombs, G.H. and Mottram, J.C. and Walkinshaw, Malcolm D. (2009) Structures of Leishmania major orthologues of macrophage migration inhibitory factor. Biochemical and Biophysical Research Communications, 380 (3). pp. 442-448. ISSN 1090-2104

Eschenlauer, Sylvain C P and Faria, Marilia S and Morrison, Lesley S and Bland, Nicolas and Ribeiro-Gomes, Flavia L and DosReis, George A and Coombs, Graham H and Lima, Ana Paula C A and Mottram, Jeremy C (2008) Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major. Cellular Microbiology, 11 (1). pp. 106-120. ISSN 1462-5814

Lanfranco, Maria F. and Loayza-Muro, Raul and Clark, Daniel and Nunez, Regina and Zavaleta, Amparo I. and Jimenez, Maribel and Meidal, Morten and Coombs, G.H. and Mottram, J.C. and Izidoro, Mario and Juliano, Maria A. and Juliano, Luiz and Arevalo, Jorge (2008) Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. Molecular and Biochemical Parasitology, 161 (2). pp. 91-100. ISSN 0166-6851

Dos Reis, Flavia C.G. and Smith, Brian O. and Santos, Camila C. and Costa, Tatiana F.R. and Scharfstein, Julio and Coombs, Graham H. and Mottram, Jeremy C. and Lima, Ana Paula C.A. (2008) The role of conserved residues of chagasin in the inhibition of cysteine peptidases. FEBS Letters, 582 (4). pp. 485-490. ISSN 0014-5793

McMillan, P.J. and Young, S.E. and Patzewitz, E.M. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2008) Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides. International Journal for Parasitology, 38. S65-S65. ISSN 0020-7519

Besteiro, Sébastien and Tonn, Daniela and Tetley, L. and Coombs, G.H. and Mottram, J.C. (2008) The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania. Journal of Cell Science, 121. pp. 561-570. ISSN 0021-9533

Ambit, A. and Fasel, N. and Coombs, G.H. and Mottram, J.C. (2008) An essential role for the Leishmania major metacaspase in cell cycle progression. Cell Death and Differentiation, 15. pp. 113-122. ISSN 1350-9047

Gornik, S.G. and Albalat, Amaya and Atkinson, R.J.A. and Coombs, Graham and Neil, D.M. (2008) The time course of early post-mortem biochemical processes in the abdominal muscle of a commercially important decapod crustacean (Nephrops norvegicus) : implications for post-catch processing. Marine and Freshwater Behaviour and Physiology, 41 (4). pp. 241-256. ISSN 1023-6244

Besteiro, Sébastien and Williams, Roderick and Coombs, Graham and Mottram, Jeremy (2007) Protein turnover and differentiation in Leishmania. International Journal for Parasitology, 37 (10). 1063–1075. ISSN 0020-7519

Carlton, J.M. and Hirt, R.P. and Silva, J.C. and Delcher, A.L. and Schatz, M. and Zhao, Q. and Wortmam, J.R. and Bidwell, S.L. and Coombs, Graham H. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315 (5809). pp. 207-212. ISSN 0036-8075

Westrop, G.D. and Goodall, Gordon and Mottram, Jeremy C. and Coombs, G.H. (2006) Cysteine biosynthesis in trichomonas vaginalis involves cysteine synthase utilizing o-phosphoserine. Journal of Biological Chemistry, 281 (35). pp. 25062-25075. ISSN 0021-9258

Besteiro, S. and Williams, R.A. and Morrison, L.S. and Coombs, G.H. and Mottram, J.C. (2006) Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. Journal of Biological Chemistry, 281 (16). pp. 11384-11396. ISSN 0021-9258

Helms, M.J. and Ambit, A. and Appleton, P. and Tetley, L. and Coombs, G.H. and Mottram, J.C. (2006) Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes. Journal of Cell Science, 119. pp. 1105-1117. ISSN 0021-9533

Williams, R.A. and Tetley, L. and Mottram, J.C. and Coombs, G.H. (2006) Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana. Molecular Microbiology, 61. pp. 655-674. ISSN 0950-382X

Cameron, P. and McGachy, H.A. and Anderson, M. and Paul, A. and Coombs, G.H. and Mottram, J.C. and Alexander, J. and Plevin, R.J. (2004) Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. Journal of Immunology, 173 (5). pp. 3297-3304. ISSN 0022-1767

Alphey, Magnus S. and Williams, Roderick and Mottram, Jeremy and Coombs, Graham and Hunter, William N. (2003) The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase : A three-domain architecture with a serine protease-like triad at the active site. Journal of Biological Chemistry, 278. pp. 48219-48227. ISSN 0021-9258

Pollock, K.G.J. and McNeil, K.S. and Mottram, J.C. and Lyons, R.E. and Brewer, J.M. and Scott, P. and Coombs, G.H. and Alexander, J. (2003) The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses. Journal of Immunology, 170 (4). pp. 1746-1753. ISSN 0022-1767

Williams, Roderick and Kelly, Sharon and Mottram, Jeremy and Coombs, Graham (2003) 3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism. Journal of Biological Chemistry, 278. pp. 1480-1486. ISSN 0021-9258

Roberts, C W and Roberts, F and Lyons, R E and Kirisits, M J and Mui, E J and Finnerty, J and Johnson, J J and Ferguson, D J P and Coggins, J R and Krell, T and Coombs, G H and Milhous, W K and Kyle, D E and Tzipori, S and Barnwell, J and Dame, J B and Carlton, J and McLeod, R and Roberts, Craig (2002) The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases, 185 (Supple). S25-S36. ISSN 0022-1899

Roberts, F and Roberts, C W and Johnson, J J and Kyle, D E and Krell, T and Coggins, J R and Coombs, G H and Milhous, W K and Tzipori, S and Ferguson, D J and Chakrabarti, D and McLeod, R (1998) Evidence for the shikimate pathway in apicomplexan parasites. Nature, 393 (6687). pp. 801-805. ISSN 0028-0836

Denton, H and Roberts, C W and Alexander, J and Thong, K W and Coombs, G H (1996) Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. FEMS Microbiology Letters, 137 (1). pp. 103-108. ISSN 0378-1097

Denton, H and Brown, S M and Roberts, C W and Alexander, J and McDonald, V and Thong, K W and Coombs, G H (1996) Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii. Molecular and Biochemical Parasitology, 76 (1-2). pp. 23-29. ISSN 0166-6851

This list was generated on Thu Apr 17 22:47:16 2014 BST.