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Ohotski, Jan and Long, Jaclyn and Orange, Clare and Elsberger, Beatrix and Mallon, Elizabeth and Doughty, J and Pyne, Susan and Pyne, Nigel and Edwards, Joanne (2012) Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. British Journal of Cancer, 106 (8). pp. 1453-1459. ISSN 0007-0920
Pyne, Nigel J and Tonelli, Francesca and Lim, Keng Gat and Long, Jaclyn and Edwards, Joanne and Pyne, Susan (2012) Targeting sphingosine kinase 1 in cancer. Advances in Biological Regulation, 52 (1). 31–38. ISSN 2212-4934
Pyne, N. J. and Tonelli, F. and Lim, K. G. and Long, J. S. and Edwards, J. and Pyne, S. (2012) Sphingosine 1 phosphate signalling in cancer. Biochemical Society Transactions, 40 (1). pp. 94-100. ISSN 0300-5127
Loveridge, Carolyn and Tonelli, Francesca and Leclercq, Tamara and Lim, Keng Gat and Long, Jaclyn S and Berdyshev, Evgeny and Tate, Rothwelle J and Natarajan, Viswanathan and Pitson, Stuart M and Pyne, Nigel J and Pyne, Susan (2010) The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. Journal of Biological Chemistry, 285 (50). pp. 38841-38852.
Long, J.S. and Fujiwara, Y. and Edwards, J. and Tannahill, C.L. and Tigyi, G. and Pyne, S. and Pyne, N.J. (2010) Sphingosine 1-phosphate receptor 4 uses HER2 (ErbB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. Journal of Biological Chemistry, 285. pp. 35957-35966. ISSN 0021-9258
Watson, C. and Long, J.S. and Orange, C. and Tannahill, C.L. and Mallon, E. and McGlynn, L.M. and Pyne, S. and Pyne, N.J. and Edwards, J. (2010) High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. American Journal of Pathology, 177 (5). pp. 2205-2215. ISSN 0002-9440
Long, J.S. and Edwards, J. and Watson, C and Tovey, S and Mair, K.M. and Schiff, R. and Natarajan, V. and Pyne, N.J. and Pyne, S. (2010) Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor-2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Molecular and Cellular Biology, 30 (15). pp. 3827-3841. ISSN 0270-7306
Tonelli, F. and Lim, K.G. and Loveridge, Carolyn and Long, J. and Pitson, S.M. and Tigyi, G. and Bittman, R. and Pyne, S. and Pyne, N.J. (2010) FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling, 22 (10). pp. 1536-1542. ISSN 0898-6568
Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.
Gillies, L. and Lee, S.C. and Long, J.S. and Ktistakis, N. and Pyne, N.J. and Pyne, S. (2009) The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cellular Signalling, 21 (5). pp. 675-684. ISSN 0898-6568
Pyne, S. and Lee, S.C. and Long, J.S. and Pyne, N.J. (2009) Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cellular Signalling, 21 (1). pp. 14-21. ISSN 0898-6568
Pyne, Nigel J. and Long, Jaclyn S. and Lee, Sue Chin and Loveridge, Carolyn and Gillies, Laura and Pyne, Susan (2009) New aspects of sphingosine 1-phosphate signaling in mammalian cells. Advances in Enzyme Regulation, 49 (1). pp. 214-221. ISSN 0065-2571
Rodgers, A. and Mormeneo, D. and Long, J.S. and Delgado, A. and Pyne, N.J. and Pyne, S. (2009) Sphingosine 1-phosphate regulation of extracellular signal regulated kinase-1/2 in embyronic stem cells. Stem Cells and Development, 18 (9). pp. 1319-1330. ISSN 1547-3287
Long, J.S. and Pyne, N.J. and Pyne, S. (2008) Lipid phosphate phosphatases form homo- and hetero-oligomers : catalytic competency, subcellular distribution and function. Biochemical Journal, 411 (2). pp. 371-377. ISSN 0264-6021
Pyne, N.J. and Waters, C. and Long, J.S.L. and Akhtar Moughal, N. and Tigyi, G. and Pyne, S. (2007) Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells. Advances in Enzyme Regulation, 47 (1). pp. 271-280. ISSN 0065-2571
Long, J.S.L. and Pyne, N.J. and Pyne, S. (2006) The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins and Other Lipid Mediators, 79 (3-4). pp. 278-286. ISSN 1098-8823
Waters, C. and Long, J.S.L. and Gorshkova, I. and Fujiwara, Y. and Connell, M. and Belmonte, K.E. and Tigyi, G. and Natarajan, V. and Pyne, S. and Pyne, N.J. (2006) Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. FASEB Journal, 20. pp. 509-511. ISSN 0892-6638
Pyne, N.J. and Long, J.S.L. and Yokoyama, K. and Tigyi, G. and Pyne, S. (2006) Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration. Biochemical Journal, 394. pp. 495-500. ISSN 0264-6021
Long, J.S.L. and Natarajan, V. and Tigyi, G. and Pyne, S. and Pyne, N.J. (2006) The functional pDGFβ receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. Prostaglandins and Other Lipid Mediators, 80. pp. 74-80. ISSN 1098-8823
Long, Jaclyn and Darroch, Peter and Wan, Kah Fei and Kong, Kok Choi and Ktistakis, Nicholas and Pyne, Nigel J and Pyne, Susan (2005) Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochemical Journal, 391 (1). pp. 25-32.