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Article

Janicova, Lucia and Rzepecka, Justyna and Rodgers, David and Doonan, James and Bell, Kara and Lumb, Felicity Elspeth and Suckling, Colin and Harnett, Margaret and Harnett, William (2016) Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens. Parasite Immunology. ISSN 0141-9838 (In Press)

Mouser, Emily E. I. M. and Pollakis, Georgios and Yazdanbakhsh, Maria and Harnett, William and de Jong, Esther C. and Paxton, William A. (2016) Brugia malayi Antigen (BmA) inhibits HIV-1 trans-infection but neither BmA nor ES-62 alter HIV-1 infectivity of DC induced CD4+ Th-cells. PLOS One, 11 (1). ISSN 1932-6203

Coltherd, J. C. and Rodgers, D. T. and Lawrie, R. E. and Al-Riyami, L. and Suckling, C. J. and Harnett, W. and Harnett, M. M. (2016) The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma. Scientific Reports, 6. ISSN 2045-2322

Rodgers, D. T. and Pineda, M. A. and Suckling, C. J. and Harnett, W. and Harnett, M. M. (2015) Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus. Lupus, 24 (13). pp. 1437-1442. ISSN 1477-0962

Bell, Kara S. and Al-Riyami, Lamyaa and Lumb, Felicity E. and Britton, Graham J. and Poole, Alastair W. and Williams, Chris M. and Braun, Ursula and Leitges, Michael and Harnett, Margaret M. and Harnett, William (2015) The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62. Immunology Letters, 168 (1). pp. 31-40. ISSN 0165-2478

Rzepecka, Justyna and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rodgers, David T. and Huggan, Judith K. and Lumb, Felicity E. and Khalaf, Abedawn I. and Meakin, Paul J. and Corbet, Marlene and Ashford, Michael L. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60. pp. 59-73. ISSN 0896-8411

Rodgers, David T. and McGrath, Mairi A. and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rzepecka, Justyna and Lumb, Felicity and Harnett, William and Harnett, Margaret M. (2015) The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice. Arthritis and Rheumatology, 67 (4). pp. 1023-1035.

Al-Riyami, Lamyaa and Rodgers, David T. and Rzepecka, Justyna and Pineda, Miguel A. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Experimental Parasitology. ISSN 0014-4894 (In Press)

Aprahamian, Tamar R. and Zhong, Xuemei and Amir, Shahzada and Binder, Christoph J. and Chiang, Lo-Ku and Al-Riyami, Lamyaa and Gharakhanian, Raffi and Harnett, Margaret M. and Harnett, William and Rifkin, Ian R. (2015) The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology, 45 (4). pp. 203-207. ISSN 0020-7519

Harnett, Margaret M. and Harnett, William and Pineda, Miguel A. (2014) The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of collagen-induced arthritis. Inflammation and Cell Signaling, 1 (3). pp. 1-19. ISSN 2330-7803

Rzepecka, Justyna and Coates, Michelle and Saggar, Moninder and Al-Riyami, Lamyaa and Coltherd, Jennifer and Tay, Hwee Kee and Huggan, Judith and Janicova, Lucia and Khalaf, Abedawn and Siebeke, Ivonne and Suckling, Colin and Harnett, Margaret and Harnett, William (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44 (9). pp. 669-674. ISSN 0020-7519

Pineda, M.A. and Al-Riyami, L. and Harnett, W. and Harnett, M.M. (2014) Lessons from helminth infections : ES-62 highlights new interventional approaches in rheumatoid arthritis. Clinical and Experimental Immunology, 177 (1). pp. 13-23. ISSN 0009-9104

Harnett, William (2014) Secretory products of helminth parasites as immunomodulators. Molecular and Biochemical Parasitology, 195 (2). pp. 130-136. ISSN 0166-6851

Pineda, Miguel A and Rodgers, David T and Al-Riyami, Lamyaa and Harnett, William and Harnett, Margaret (2014) ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints. Arthritis and Rheumatism, 66 (6). 1492–1503. ISSN 0004-3591

Pineda, Miguel A. and Lumb, Felicity and Harnett, Margaret M. and Harnett, William (2014) ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. Molecular and Biochemical Parasitology, 194 (1-2). pp. 1-8. ISSN 0166-6851

Rodgers, David T. and Pineda, Miguel A. and McGrath, Mairi A. and Al-Riyami, Lamyaa and Harnett, William and Harnett, Margaret M. (2014) Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints. Immunology, 141 (3). 457–466. ISSN 0019-2805

Rzepecka, Justyna and Harnett, William (2013) Impact of worms and their products on eosinophils and neutrophils in experimental asthma. Current Molecular Medicine, 13 (7). pp. 1192-1202. ISSN 1566-5240

Rzepecka, Justyna and Siebeke, Ivonne and Coltherd, Jennifer and Kean, Dorothy and Steiger, Christina and Al-Riyami, Lamyaa and McSharry, Charles and Harnett, Margaret and Harnett, William (2013) The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. International Journal for Parasitology, 43 (3-4). 211–223. ISSN 0020-7519

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Rodgers, David and Harnett, Margaret and Harnett, William (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis : Helminth-based synthetic compound protects against CIA. Journal of Medicinal Chemistry, 56. pp. 9982-10002. ISSN 0022-2623

Ball, Dimity and Tay, Hwee Kee and Bell, Kara and Coates, Michelle and Al-Riyami, Lamyaa and Rzepecka, Justyna and Harnett, William and Harnett, Margaret (2013) Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62. Journal of Parasitology Research, 2013. (In Press)

Pineda, Miguel and McGrath, Mairi and Smith, Pauline and Al-Riyami, Lamyaa and Rzepecka, Justyna and Gracie, Alastair and Harnett, William and Harnett, Margaret (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64 (10). 3168–3178. ISSN 0004-3591

Alcocer, M. J. C. and Murtagh, G. J. and Mirotti, L. and Brans, A. and Harnett, W. and Rundqvist, L. and Larsson, G. (2011) The allergenicity of 2S plant albumins : a Brazilnut model system. Clinical and Experimental Allergy, 41 (12). p. 1827. ISSN 0954-7894

Harnett, William and Goodridge, Helen and Allen, Janet and Harnett, Margaret (2011) Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62. Experimental Parasitology. ISSN 0014-4894

Al-Riyami, Lamyaa and Rzepecka, Justyna and Khalaf, Abedawn and Suckling, Colin and Harnett, M. and Harnett, William (2010) Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways : Poster abstract. Immunology, 131 (Supple). p. 164. ISSN 0019-2805

Harnett, W. and Harnett, M.M. (2010) Helminth-derived immunomodulators : can understanding the worm produce the pill? Nature Reviews Immunology, 10 (4). pp. 278-284. ISSN 1474-1733

Harnett, W. and Rzepecka, J. and Houston, K.M. (2010) How do nematodes transfer phosphorylcholine to carbohydrates? Trends in Parasitology, 26 (3). pp. 114-118. ISSN 1471-4922

Harnett, M.M. and Melendez, A.J. and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159 (3). pp. 256-67. ISSN 0009-9104

Al-Riyami, L. and Wilson, E.H. and Watson, C.A. and Harnett, W. (2009) T-helper type 1 responses to the bcg vaccine component ppd in mice are unaffected by the filarial nematode immunomodulatory molecule es-62. Journal of Parasitology, 95 (5). pp. 1201-1204.

Al-Riyammi, L. and Harnett, W. (2009) The clinical potential of worms and their products in treating inflammatory diseases. Current Immunology Reviews, 5 (1). pp. 35-41. ISSN 1573-3955

Houston, K.M. and Babayan, S.A. and Allen, J.E. and Harnett, W. (2009) Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline? Parasitology, 135 (1). pp. 55-61. ISSN 0031-1820

McGrath, M.A. and Kean, D.E. and McInnes, I.B. and Harnett, W. and Harnett, M.M. (2008) Dissection of the immunomodulatory effects of ES-62 on inflammatory autoimmune disease. Immunology, 125 (s1). pp. 122-123. ISSN 0019-2805

Noronha, A. and Liang, Y. and Harnett, W. and Harnett, M.M. and Stucchi, A. and Becker, J. and Farraye, F.A. and Ganley-Leal, L. (2008) TLR2 and TLR4 regulate B cell responses in human inflammatory bowel disease. Inflammatory Bowel Diseases, 14 (12). S8-S8. ISSN 1078-0998

Mammen, A. and Farraye, F.A. and Liang, Y. and Harnett, W. and Shin, H. and Harnett, M.M. and Nikolajczyk, B. and Ganley-Leal, L. (2008) The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis. American Journal of Tropical Medicine and Hygiene, 79 (6). pp. 337-338. ISSN 0002-9637

Harnett, W. and Harnett, M.M. (2008) Parasitic nematode modulation of allergic disease. Current Allergy and Asthma Reports, 8 (5). pp. 392-397. ISSN 1529-7322

Harnett, W. and Harnett, M.M. (2008) Lymphocyte hyporesponsiveness during filarial nematode infection. Parasite Immunology, 30 (9). pp. 447-453. ISSN 0141-9838

Harnett, W. and Harnett, M.M. (2008) Therapeutic immunomodulaors from nematode parasites. Expert Reviews in Molecular Medicine, 10 (e18). ISSN 1462-3994

Marshall, F.A. and Watson, K.A. and Garside, P. and Harnett, M.M. and Harnett, W. (2008) Effect of activated antigen-specific b cells on es-62-mediated modulation of effector function of heterologous antigen-specific t cells in vivo. Immunology, 123 (3). pp. 411-425. ISSN 0019-2805

Houston, Katrina M. and Sutharsan, Ratneswary and Steiger, C.N. and Schachter, Harry and Harnett, W. (2008) Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. Molecular and Biochemical Parasitology, 157 (1). pp. 88-91. ISSN 0166-6851

Al-Riyami, Lamyaa and Egan, C.A. and Bradley, J.E. and Lustigman, S. and Harnett, W. (2008) Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite Immunology, 30 (5). pp. 304-308. ISSN 0141-9838

Harnett, M.M. and Kean, Dorothy E. and Boitelle, A. and McGuiness, S. and Thalhamer, T. and Steiger, C.N. and Egan, Caitlin and Al-Riyami, Lamyaa and Alcocer, Marcos J.C. and Houston, Katrina M. and Gracie, J.A. and McInnes, I.B. and Harnett, W. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67 (4). pp. 518-523. ISSN 0003-4967

Melendez, A.J. and Harnett, M.M. and Pushparaj, P.N. and Wong, W.S.F. and Tay, H.K. and McSharry, C.P. and Harnett, W. (2007) Inhibition of FceRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nature Medicine, 13 (11). pp. 1375-1381. ISSN 1078-8956

Kean, Dorothy E. and Goodridge, Helen S. and McGuinness, Stephen and Harnett, Margaret M. and Alcocer, Marcos J.C. and Harnett, William (2006) Differential polarisation of immune responses by plant 2S seed albumins, Ber e 1 and SFA8. Journal of Immunology, 177. pp. 1561-1566. ISSN 0022-1767

Goodridge, H.S. and Marshall, F.A. and Else, K.J. and Houston, K.M. and Egan, C. and Al-Riyami, L.R. and Liew, F.Y. and Harnett, W. and Harnett, M.M. (2005) Immunomodulation via Novel Use of TLR4 by the Filarial Nematode Phosphorylcholine-Containing Secreted Product, ES-621. Journal of Immunology, 174 (1). pp. 284-293. ISSN 0022-1767

Goodridge, Helen S. and Marshall, Fraser A. and Else, Kathryn J. and Houston, Katrina M. and Egan, Caitlin and Al-Riyami, Lamyaa and Liew, Foo-Yew and Harnett, William and Harnett, Margaret M. (2005) Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine (PC)-containing secreted product, ES-62. Journal of Immunology, 174. pp. 284-293. ISSN 0022-1767

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M.M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode derived phosphoryleholine-containing glycoprotein, ES-62. Arthritis and Rheumatism, 48 (9). S349-S349. ISSN 0004-3591

Smith, R.E. and Patel, V. and Seatter, S.D. and Deehan, M.R. and Brown, M.H. and Brooke, G.P. and Goodridge, H.S. and Howard, C.J. and Rigley, K.P. and Harnett, W. and Harnett, M.M. (2003) A novel MyD-1 (SIRP-1{alpha}) signaling pathway that inhibits LPS-induced TNF{alpha} production by monocytes. Blood, 102. pp. 2532-2540. ISSN 0006-4971

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M.M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. Arthritis Research and Therapy, 5 (Suppl ). p. 52. ISSN 1478-6354

Stepek, G and Auchie, M and Tate, R and Watson, K and Russell, D G and Devaney, E and Harnett, W (2002) Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific. Parasitology, 125 (Pt 2). pp. 155-64. ISSN 0031-1820

Book Section

Harnett, W. and Harnett, M.M. (2009) Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62. In: Pathogen-Derived Immunomodulatory Molecules. Advances in Experimental Medicine and Biology, 666 . Landes Bioscience, pp. 88-94. ISBN 978-1-4419-1600-6

Conference or Workshop Item

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. In: 23rd European Workshop for Rheumatology Research, 2003-03-27.

This list was generated on Sat May 28 13:23:30 2016 BST.